Topic: The roles of mir-125b in immunity and leukemic development
Lecturer: Alex Steven (Yick-Lun) So
Time: 15:00pm-16:00pm. April 14, 2014. Monday
Location: IBMS Academic Report Hall（Room 3401, Building 703. Dushu Lake Campus）
AlexSteven (Yick-Lun) So,Ph.D.
PROFILE
Immunologist and molecular biologistspecializing in microRNA-mediated leukemic development using mouse models.Experienced in mentoring, grant writing, and scientific presentation.
EDUCATION
California Institute of Technology,Pasadena, CA 2008 – present Post-Doctoral Fellow (Biology)
University of California SanFrancisco, San Francisco, CA 2002 – 2007 Ph.D., Chemistry andChemical Biology
University of Westminster,London,England 2001 Study Abroad Program
Skidmore College, Saratoga Springs, NY1995 - 1998 B.A.,Chemistry Major with Biochemistry Concentration
RESEARCH EXPERIENCE
California Institute ofTechnology,Pasadena, CA 2008 - Present Post-Doctoral Fellow
1）Investigatingthe cellularand molecular mechanism by which microRNA-125b regulates bothhematopoiesis aswell as leukemia in mice
2）Determiningthe role of theBach1 protein in autoimmunity, T cell immunity, and developmentof antigenpresenting cells in mice.
University of California SanFrancisco,San Francisco, CA2007 –2008 Staff Research Associate
1）Studiedthe mechanism bywhich the glucocorticoid receptor initiates and maintain scircadian rhythm instem cells
2）Examinedthe functional roleof circadian rhythm genes in adipocyte cell fate
University of California SanFrancisco, San Francisco,CA2002 – 2007Ph.D. Student
1）Examinedthe determinants ofcell- and gene-specific transcriptional regulation by the glucocorticoidreceptor
2）Applied computational andconservation analyses to predict global occupancy of glucocorticoid receptorbinding in mammalian genomes.
PUBLICATIONS
1) So AY* & Zhao JL*,Baltimore D, “The Yin and Yang of microRNAs:leukemia and immunity” Immun. Rev,2012.*Co-first authors
2) So AY, Garcia-FloresY, Minisandram A, Martin A, Taganov K, BoldinM, Baltimore D, “Regulation Of APCDevelopment,ImmuneResponse, and Autoimmunity by Bach1/HO-1 Pathway in Mice” Blood,2012.
3)Chaudhuri AA* & SoAY*,Mehta A, Minisandram A, Sinha N, Jonsson VD, Rao DS, O’Connell RM,Baltimore D,“Oncomir MiR-125b RegulatesHematopoiesis by Targeting the Gene Lin28A” PNAS,2012. *Co-first authors
4)Chaudhuri AA* & SoAY*, Sinha N, Gibson WS, O’ConnellRM, Baltimore D,“MicroRNA-125b Potentiates Macrophage Activation” Journal ofImmunology,2011.*Co-first authors
5)Maria Jose Costa* & SoAY*, Kaasik K, Pillsbury ML, Fu YH,Ptacek LJ, Yamamoto KR,Feldman BJ, “Circadian Clock Gene Period3 is anInhibitor of the Adipocyte CellFate” JBC, 2011.*Co-first authors
6) So AY, de la Fuente E,Walter P, Shuman M, Bernales S, “Theunfolded protein response during prostatecancer development” Cancer MetastasisRev, 2009.
7) So AY, Bernal TU,Pillsbury M, Yamamoto, KR, Feldman BJ,“Glucocorticoid regulation of thecircadian clock modulates glucosehomeostasis” PNAS, 2009.
8) So AY, Cooper S.,Feldman BJ, Manuchehri M, Yamamoto KR,“Conservation Analysis Predicts In VivoOccupancy of Glucocorticoid ReceptorBinding Sequences at Glucocorticoid-InducedGenes” PNAS, 2008.
9) So AY, Chivorapol C,Bolton EC, Li H, Yamamoto KR, “Determinants OfCell- and Gene-Specific TranscriptionalRegulationby the Glucocorticoid Receptor” PLoS Genetics, 2007.