Principal Investigator
Fangfang Zhou Ph.D. Professor of IBMS Professor Fangfang Zhou got her Ph.D. degree in the department of Bioscience and Technology at Tsinghua University in the year of 2008. She worked as a Post-doctor and Researcher in Leiden University Medical Center in the Netherland from the year 2008 to 2013. Then she was promoted as a research assistant professor from the year 2013 to 2014. At the end of 2014, she joined Soochow University and became a full professor and independent principle investigator at the Institutes of Biology and Medical Sciences, Soochow University. Professor Zhou's research mainly focused on the regulation of innate immunity. She has published more than 70 papers as the major contributor in peer-reviewed journals including Nature Immunology, Nature Cell Biology, Molecular Cell, Nature Communications, Advanced Materials and Advanced Sciences etc.
Research Interest:
Research of Prof. Zhou now focused on the mechanism of innate immune regulation. Main directions are: 1. Physiological and pathological regulation of innate immune response; 2. Mechanism and intervention strategies of innate immunity against virus; 3. Mechanism of the tumor progression and tumor cells escaping from the innate immune surveillance.
Selected publication（*Corresponding author; #Co-first authors）: 1. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. Zong Z, Xie F, et al., Zhou F*. Cell. 2024 2. TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence. Ren J, Wang S, Zong Z, Pan T, et al., He X, Zhou F*, Zhang L*. Nature Communications. 2024 3. iProPhos: A Web-Based Interactive Platform for Integrated Proteome and Phosphoproteome Analysis. Zou J, Qin Z, Li R*, et al., Zhou F*, Zhang L*. Molecular Cellular Proteomics. 2024 4. TBK1: a new target for overcoming cancer immunotherapy resistance. Guan J, Zhang L*, Zhou F*. Science China Life Sciences. 2024 5. DeSUMOylation by SENP1 inhibits MAVS aggregation and antagonizes IRF3 activation. Dai T, Zhang L, Ran Y, et al., Lin S*, Zhang L*, Zhou F*. Nature Structure & Molecular Biology. 2023 6. Capturing Protein-Protein Interactions with Acidic Amino Acids Reactive Cross-Linkers. Liao QQ, Shu X, Sun W, Mandapaka H, Xie F, Zhang Z, Dai T, Wang S, Zhao J, Jiang H, Zhang L, Lin J, Li SW, Coin I, Yang F, Peng J, Li K*, Wu H*, Zhou F*, Yang B*. Small. 2023 7. The role of TIA1 and TIAL1 in germinal center B cell function and survival. Wang Y, Liu J, Zhou F*. Cellular Molecular Immunology. 2023 8. Biomolecular condensates: formation mechanisms, biological functions and therapeutic targets. Niu X, Zhang L, Wu Y, et al., Liu J*, Zhang L*, Zhou F*. MedComm. 2023 9. Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood. Li R, Zou J, Pei D, Pan T, et al., Chen Y*, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2023 10. The loss of epigenetic information: not only consequences but a cause of mammalian aging. Pan C, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2023 11. The fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses. Z Zong, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2023 12. Motile cilia and microvillar: accomplices of SARS-CoV-2 in penetrating mucus barrier and infecting airway epithelium. Su P, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2023 13. A review of gut microbiota-derived metabolites in tumor progression and cancer therapy. Yang Q, Wang B, Zheng Q, et al., Meng X*, Zhou F*, Zhang L*. Advanced Science. 2023 14. A review of extracellular vesicles in COVID-19 diagnosis, treatment and prevention. Su P, Wu Y, Xie F, Zeng Q, et al., Meng X*, Zhou F*, Zhang L*. Advanced Science. 2023 15. WNK1, a molecular crowding sensor, links phase separation to cellular physiological stress. Lan T, Zhou F*, Zhang L*. MedComm. 2023 16. Breast Cancer Cell-derived Extracellular Vesicles Promote CD8+ T cell Exhaustion via TGF-β type II receptor Signalling. Xie F, Zhou X, et al., Zhang L*, Zhou F*. Nature Communications. 2022 17. LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation. Wang S, et al., Zhang L*, Zhou F*. Cell Reports. 2022 18. Emerging implications of phase separation in cancer. Ren J, Zhang Z, Zong Z, Zhang L*, Zhou F*. Advanced Science. 2022 19. Wang Y，Fang X, Wang S, Wang B, Chu F, Zhang L*, Zhou F*. The role of O-GlcNAcylation in innate immunity and inflammation. Journal of Molecular Cell Biology. 2022 20. Wang B, Zhang L, Zhou F*. Zhang L*. Potential mechanisms by which impaired ketogenesis links metabolism to T-cell dysfunction in patients with severe COVID-19. Medcomm. 2022 21. Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/7 in innate antiviral immunity. Qin Z, Fang X, et al., Zhou F*, Zhang L*. Nature Immunology. 2022 22. IRF3 and IRF7 require SIRT1 for liquid-liquid phase separation and transactivation of INF-I. Zhou F*, Zhang L*. Nature Immunology (Research Briefing). 2022 23. Targeting USP8 inhibits Cancer Progression and Prevents Extracellular-Vesicle TβRII-Induced Exhaustion of CD8+ T cells. Xie F, Zhou X, et al., Zhou F*, Zhang L*. EMBO Journal. 2022 24. Microbiota in tumors: from understanding to application. Xie Y, Xie F, Zhou X, et al., Zhang L*, Zhou F*. Advanced Science. 2022 25. SARS-CoV-2 Omicron variant: recent progress and future perspectives. Fan Y, Li X, Zhang L, Wan S, Zhang L*, Zhou F*. Signal Transduction and Targeted Therapy. 2022 26. Cuproptosis: a new form of programmed cell death. Wang Y, Zhang L, Zhou F*. Cellular & Molecular Immunology. 2022 27. Guan J, Zhang L*, Zhou F*. PI3K-PANK4: a new target for de novo synthesis of coenzyme A. Molecular Biomedicine. 2022 28. Wei X, Xie F, Zhou X, Yan H, Liu T, Huang J*, Wang F*, Zhou F*, Zhang L*. Developments in the understanding of pyroptosis and its potential role in the treatment of inflammation and cancer. Cellular & Molecular Immunology. 2022 29. SUMOylation in Viral Replication and Antiviral Defense. Fan Y, Li X, Zhang L,et al., Zhang L*, Zhou F*. Advanced Science. 2022 30. STING, a critical contributor to SARS-CoV-2 immunopathology. Li H, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2022 31. Ferroptosis in cancer and cancer immunotherapy. Zhao L, Zhou X, Xie F, Zhang L, et al., Zhou F*, Chen J*, Zhang L*. Cancer Communications. 2022 32. Novel pyroptosis-independent functions of gasdermins. Qin Z, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2022 33. Post-translational modifications in liquid-liquid phase separation: a comprehensive review. Li J, Zhang M, et al., Zhou F*, Zhang L*. Molecular Biomedicine. 2022 34. Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions. Wang B, Zhang L, et al., Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2022 35. ADP-riboxanation: a new pyroptosis evasion strategy. Li H, Zhou F*, Zhang L*. J Mol Cell Biol. 2022 36. Wang S, Dai T, Qin Z, Pan T, et al., Zhou F*. Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity via elevating MAVS activity. Nature Cell Biology. 2021 37. Xie F, Su P, Pan T et al., Zhang L*, Zhou F*. Engineering extracellular vesicles enriched with palmitoylated ACE2 as COVID-19 therapy. Advanced Materials. 2021 38. ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A Review. Zhang M, et al., Zeng L*, Zhou F*. Front Cell Dev Biol. 2021 39. Wang B, Dai T, Ren J, et al., Zhou F*.Protein N-myristoylation: functions and mechanisms in control of innate immunity.Cellular & Molecular Immunology. 2021 40. Zong Z, Wei Y, Ren J, et al., Zhou F*. The intersection of COVID-19 and cancer: signaling pathways and treatment implications. Molecular Cancer. 2021 41. Xie Y, Xie F, Zhou F*. Targeted anti-tumor immunotherapy using tumor infiltrating cells. Advanced Science. 2021 42. Dong Y, Dai T, Wang B, Zhou F*. The way of SARS-CoV-2 vaccine development: success and challenges.Signal Transduction and Targeted Therapy.2021 43. Fan Y, Zhang L*, Zhou F*. cGAS-like receptors: new RNA sensors in Drosophila. Signal Transduction and Targeted Therapy.2021 44. Guo H, Zhou L, et al., Zhou F*. Promising immunotherapies against COVID-19. Advanced Therapeutics. 2021 45. Zhang Y, Qin Z, Sun W, Chu F, Zhou F*.Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases.Frontiers in Immunology. 2021 46. Gao L, Zhou F*.Comprehensive Analysis of RUNX and TGF-β Mediated Regulation of Immune Cell Infiltration in Breast Cancer.Frontiers in Cell and Developmental Biology. 2021 47. Zhang Z, Fang X, et al., Zhou F*. Acetylation-dependent deubiquitinase OTUD3 controls MAVS activation in innate antiviral immunity. Molecular Cell. 2020 48. Dong Y, Dai T, Wei Y, et al., Zheng M*, Zhou F*. A systematic review of SARS-CoV-2 vaccine candidates. Signal Transduction and Targeted Therapy. 2020 49. Zhou X, Xie F, Wang L, et al., Zhou F*. The function and clinical application of extracellular 50. Wang S*, Zhou L, et al., Zhou F*. The Crosstalk Between Hippo-YAP Pathway and innate Immunity. Frontiers in Immunology. 2020 51. Dong Y, Dai T, et al.,Zhou F*. Coronavirus in continuous flux: from SARS-CoV to SARS-CoV-2. Advanced Science. 2020 52. Zong Z, Zhang Z, et al.,Zhou F*. The functional deubiquitinating enzymes in control of innate antiviral immunity. Advanced Science. 2020 53. Jin K, et al., Zhou F*. An Effective Platform for Cancer Immunotherapy: Pooled Knockin Targeting for Genome Engineering Immunotherapies. Signal Transduction and Targeted Therapy. 2020 54. Cheng Z, Dai T, et al.,Zhou F*. The interaction between cGAS-STING pathway and pathogens. Signal Transduction and Targeted Therapy. 2020 55. Zhou L, Zhang Y, et al.,Zhou F*. A dual role of type I interferons in antitumor immunity. Advanced Biosystems. 2020 56. Xie F, Zhou X, Fang MY, et al.,Zhou F*. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy. Advanced Science. 2019 57. Gao L, Wang L, Dai T, Jin K, Zhang Z, et al.,Zhou F*, Zhang L*. Tumor-derived exosomes antagonize innate antiviral immunity. Nature Immunology. 2018 58. Wang S, et al., Zhang L*, Zhou F*. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation. Nature Immunology. 2017 59. Zhang L*, Xie F, et al., Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death Differentiation. 2017 60. Xie F, Jin K, Shao L, et al., Zhou F*, Zhang L*. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nature Communications. 2017 61. Li Y, et al., Zhou F*, Zhang L*. c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway. Cancer Research. 2016 62. Zhang J, et al., Zhang L*, Zhou F*. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell. 2014 63. Zhang L*,Zhou F*, ten Dijke P*. (2013) Signaling interplay between transforming growthfactor-β receptor and PI3K/AKT pathways in cancer. Trends in Biochemical Sciences. 2013 64. Zhang L,Zhou F*, et al., Ten Dijke P*. TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Molecular Cell. 2013 65. Zhang L, Zhou F*, et al., ten Dijke P*. (2012) USP4 is regulated by Akt phosphorylation and directly deubiquitinates TGF-β type Ireceptor. Nature Cell Biology. 2012 66. Zhang L,Zhou F*, et al., Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation. Molecular Biology of the Cell. 2011 E-mail: zhoufangfang@suda.edu.cn Office：Dushu lake 703-B314
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