Principal Investigator
Hebin Liu Ph.D.
Professor of IBMS
Dr. Hebin Liu is a Professor of Immunology at Institutes of Biomedical Science (IBMS), Soochow University School of Medicine. He received a PhD in Internal Medicine (infectious diseases) from Zhejiang University School of Medicine (2004), and a PhD in Molecular Biology from Umeå University, Sweden (2005), followed by postdoctoral fellowships in Immunology at Imperial College London (2005-2006) and at University of Cambridge (2006-2012). Before he joined Soochow University as a principal investigator, Dr. Liu served as a faculty member and a tenured associate professor at Xi’an Jiaotong-Liverpool University (XJTLU).
We are interested in probing howdysregulation of hematopoietic cell adaptors contributes tothe pathogenesis of infectious diseases, immune-mediated diseases and cancer, and in further investigating their potential as immunotherapeutic targets. The current research in Dr. Liu’s lab has focused on issues relating to:
1) Signaling via immune adaptors such as SLP-76 and ADAP in immune-mediated diseases and cancer;
2) Immune regulation by adaptor proteins in immunity to and immune evasion by RNA viruses;
3) GITR signaling in the pathogenesis of breast cancer;
4) Nuclear pore complex (NPC) as signaling platforms in health and disease.
Selected publications:
1. Yang, N., Y. Xiong, Y. Wang, Y. Yi, J. Zhu, F. Ma, J. Li, and H. Liu*, ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages. J Immunol 2021 206: 814-826.
2. Xiong Y, Yi Y, Wang Y, Yang N, Rudd CE and Liu H*, Ubc9 interacts with and SUMOylates the TCR adaptor SLP-76 for NFAT transcription in T cells. J Immunol 2019 Dec 1;203(11):3023-3036.
3. Ye C, Yu Z, Xiong Y, Wang Y, Ruan Y, Guo Y, Chen M, Luan S, Zhang E, and Liu H*, STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction. FASEB J. 2019 Jan;33 (1):286-30.
4. Xiong Y, Ye C, Yang N, Li M, and Liu H*, Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion. J Immunol 2017, 199: 4142-4154.
5. Ye C, Wang Y, Zhang E, Han X, Yu Z, and Liu H*, VP1 and VP3 are required and sufficient for translation initiation of uncapped IBDV genomic dsRNA. J Virol. 2018 Jan 2;92(2): e01345-17.
6. Ye C, Han X, Yu Z, Zhang E, Wang L, and Liu H*, Infectious Bursal Disease Virus Activates c-Src To Promote alpha4beta1 Integrin-Dependent Viral Entry by Modulating the Downstream Akt-RhoA GTPase-Actin Rearrangement Cascade. J Virol. 2017 Jan 18; 91(3): e01891-16.
7. Liu H*, Thaker YR, Stagg L, Schneider H, Ladbury JE and Rudd CE*, SLP-76 sterile alpha motif (SAM) and individual H5 alpha helix mediate oligomer formation for microclusters and T-cell activation. J Biol Chem 2013, 288(41): 29539-29549.
8. Liu H, Schneider H, Recino A, Richardson C, Goldberg MW, and Rudd CE, The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells. Mol Cell 2015, 59(5): 840-849（faculty 1000特评）.
9. Liu H, Purbhoo MA, Davis DM, and Rudd CE, SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering. Proc Natl Acad Sci U S A 2010, 107(22): 10166-10171.
If you are interested in a postdoctoral position, a PhD position or doing your Master’s project in the lab please contact Dr. Liu directly by e-mail.
Mailing address and contact:
199 Ren’ai Road, Suzhou, 215123,
Jiangsu Province, China
Institutes of Biology and Medical Sciences (IBMS),
Soochow University School of Medicine
Email: hbliu@suda.edu.cn (Preferred)
Tel.: +86 (0) 512 65882135