GRANTS

1 The pre-clinical study of immune characters and special preventive strategies for M.tuberculosis latent infection.

National Science and Technology Major Project, 20 350 000 RMB

Chief scientist: Sidong Xiong

  

2 The mechanism study of autoimmune recognition and regulation

National Natural Science Foundation of China--Major Program, 10 000 000 RMB

Chief scientist: Sidong Xiong

  

3 The molecular basis and regulation mechanism for the specific recognition of auto antigens and their effects on auto immune response

Major State Basic Research Development Program of China (973 Program), 6 500 000 RMB

Program P.I.: Sidong Xiong

  

4 Pharmaceutical development center based on immune microenvironment

National Science and Technology Major Project, 4 160 000 RMB

Program P.I: Yunsen Li

  

5 The basic study of vaccines and adjuvants for persistent infection

Major State Basic Research Development Program of China (973 Program), 1 730 000 RMB

Section P.I.: Chunsheng Dong

  

6 Study on autoreactive immune responses in RA

Major State Basic Research Development Program of China (973 Program), 3 250 000 RMB

Program P. I.: Xiaoming Gao

  

7 The generation and functions of regulatory antibodies in autoimmune recognition and regulation

National Natural Science Foundation of China--Major Program, 3 000 000 RMB

Program P. I.: Xiaoming Gao

  

8  The immune regulatory role of IL-1a in liver chronic inflammation and tumor development

National Natural Science Foundation of China, 550 000 RMB

P. I.: Haiyan Liu

  

9The evasion of the host innate immune signaling pathway by human herpes viral    deubiquitinase (DUB)

National Natural Science Foundation of China, 1 000 000 RMB

P. I.: Chunfu Zheng

  

10, Roles of Calreticulin in immunoregulation and tumor surveillance

National Natural Science Foundation of China, 900 000 RMB

P. I.: Xiaoming Gao

  

11Ubiquitination of IFNs activated antiviral protein Viperin and its effect on aniviral function of IFNs

National Natural Science Foundation of China, 900 000 RMB

P. I.: Hui Zheng

  

12Role of membrane-bound lactoferrin in B-cell functions and the associated molecular mechanisms

National Natural Science Foundation of China, 800 000 RMB

P. I.: Jun Wang

  

13The role and molecular mechanism of HMGB1 in ER stress-associated inflammation in viral mvocarditis

National Natural Science Foundation of China, 800 000 RMB

Investigator: Yan Yue

  

14The generation and functional study of ALD-DNA induced SLE animal model

National Natural Science Foundation of China, 1 300 000 RMB

P. I.: Sidong Xiong

  

15Crosstalk between hemidesmosomes and actin cytoskeleton in the epidermis

National Natural Science Foundation of China, 850 000 RMB

P. I.: Huimin Zhang

  

16Molecular mechanism of chitosan on intestinal CD11b+ DC enhanced B cell secretion of specificity sIgA

National Natural Science Foundation of China, 800 000 RMB

P. I.: Wei Xu

  

17The function and mechanism of Cbl-b/C-Cbl in inhibiting the development of CD8+ DC

National Natural Science Foundation of China, 800 000 RMB

P. I.: Jinping Zhang

  

18Vector and pathogens: Tick innate immune signaling pathway and their roles in anti-bacterial infection

National Natural Science Foundation of China, 700 000 RMB

P. I.: Jianfeng Dai

  

19The molecular study of CVB3 viral-like particle assembly

National Natural Science Foundation of China, 700 000 RMB

P. I.: Chunsheng Dong

  

20The GVL effect of donor NK cells and IL-15 in allogeneic hematopoietic stem cell transplantation

National Natural Science Foundation of China, 600 000 RMB

P. I.: Haiyan Liu

  

21The role of a novel mucosal delivery system targeting to M cell

National Natural Science Foundation of China, 600 000 RMB

Investigator: Yan Yue

  

22,Screening of HSV-1proteins interacting with important innate immunity signaling molecules by reverse two-hybrid system, and investigation of the molecular mechanisms through which they interfere with innate immunity.

National Natural Science Foundation of China, 580 000 RMB

P. I.: Chunfu Zheng

  

23Study on novel immune receptors specific for glycans

National Natural Science Foundation of China, 350 000 RMB

P. I.: Xiaoming Gao

  

24The role of donor NK cells and IL-15 in the promotion of engraftment during nonmyeloablative allo-HSCT

National Natural Science Foundation of China, 350 000 RMB

P. I.: Haiyan Liu

  

25The gender different MCP1/IKK signaling in myocardial macrophages from CVB3 induced viral myocarditis mice

National Natural Science Foundation of China, 340 000 RMB

P. I.: Sidong Xiong

  

26Mechanism of innate immune molecule TREM2 inherent identification, the response and the negative control of Mycobacterium tuberculosis

National Natural Science Foundation of China, 300 000 RMB

P. I.: Wei Xu

  

27Molecular mechanism of the synergistic effects if apolipoprotein E4 ans Herpes Simplex Virus Type 1 infection in Alzheimer’s Disease.National Natural Science Foundation of China

National Natural Science Foundation of China, 280 000 RMB

Investigator: Jie Li

  

28Membrane bound lactoferrin function as a new pattern recognization receptor

National Natural Science Foundation of China, 230 000 RMB

Investigator: Hongliang Dong

  

29Role and mechanism for DDX25 promoting Dengue virus infection

National Natural Science Foundation of China, 230 000 RMB

Investigator: Tingting Feng

  

30Function and mechanism of mir-184 in recurrent spontaneous abortion

National Natural Science Foundation of China, 230 000 RMB

Investigator: Fulu Dong

  

31MMP3 activates NFkB in nucleus: the novel anti-Dengue virus function of MMP3

National Natural Science Foundation of China, 250 000 RMB

P. I.: Jianfeng Dai

  

32Studies on biochemical and functional properties of soluble calreticulin in serum % synovial fluid of patients with rheumatoid arthritis

National Natural Science Foundation of China, 250 000 RMB

Investigator: Fangyuan Gong

  

33Role of ZBTB24 in adaptive immunity and the underlying mechanisms

National Natural Science Foundation of China, 200 000 RMB

P. I.: Jun Wang

  

34mir-29b2 regulates the T1/T2 B cell development.

National Natural Science Foundation of China, 200 000 RMB

Investigator: Fei Xia

  

35The effect of the novelIL-15 isoform during the autoimmune disease

National Natural Science Foundation of China, 230 000 RMB

Investigator: Bo Hu

  

36Recombinant calreticulin activates regulatory B cells and it’s underlying mechanisms.

National Natural Science Foundation of China, 230 000 RMB

P. I.: Chao Hong

  

37The identification and characterization of cellular factor related to HIV-1 pre integration complex

National Natural Science Foundation of China, 220 000 RMB

P. I.: Chunsheng Dong

  

38,Characterization of antagonizing mechanism of innate immunity by Varicella-Zoster Virus immediate-early protein ORF61.

National Natural Science Foundation of China, 220 000 RMB

Investigator: Shuai Wang

  

39Study on linear ion trap MS methods for identification of tumor-associated glycospingolipids

National Natural Science Foundation of China, 200 000 RMB

P. I.: Yunsen Li

  

40The endoplasmic reticulum stress in viral myocarditis: role and mechanism study

Ph.D. Programs Foundation of Ministry of Education of China120 000 RMB

P. I.: Sidong Xiong

  

41Structure basis responsible for the immune recognition of oligosaccharide

Ph.D. Programs Foundation of Ministry of Education of China120 000 RMB

P. I.: Xiaoming Gao

  

42The role of donor NK cells in the promotion of engraftment during allogeneic bone marrow transplantation

Ph.D. Programs Foundation of Ministry of Education of China60 000 RMB

P. I.: Haiyan Liu

  

43Establishment and application of a new method for treatment of tuberculosis.

Ph.D. Programs Foundation of Ministry of Education of China40 000 RMB

Investigator: Xingmei Qi

  

44Membrane-bound lactoferrin functions as a new mitogen receptor on B cells

Ph.D. Programs Foundation of Ministry of Education of China40 000 RMB

Investigator: Hongliang Dong

  

45The generation and application of a novel CPE30-DNA-Chitosan delivery system targeting to M cell

Ph.D. Programs Foundation of Ministry of Education of China40 000 RMB

Investigator: Yan Yue

  

46Generation and functional study of coxsackievirus B3 virus-like particle in viral myocarditis.

Overseas returnee research fund of Ministry of Education of China30 000 RMB

P. I.: Chunsheng Dong

  

47Role and mechanism for DDX25 promoting Dengue virus infection

National Science Foundation for Post-doctoral Scientistsof China50 000 RMB

Investigator: Tingting Feng

  

48The roles of protein ubiquitination and deubiquitination in IFNs induced antiviral signaling.

JiangSu Province Natual Science Fund for Distinguished Young Scholars1 000 000 RMB

P. I.: Hui Zheng

  

49The pathogenesis and preventive strategies study for viral induced myocarditis

JiangSu Province Natual Science Foundation Inovation Project, 1 000 000 RMB

P. I.: Sidong Xiong

  

50Identification and analysis of oligosaccharide immune receptors

JiangSu Province“333”project, 250 000 RMB

P. I.: Xiaoming Gao

  

51The innate recognition of DNA and its role in the pathogenesis of SLE

JiangSu Province“333”project, 200 000 RMB

P. I.: Sidong Xiong

  

52LPS promote the proliferation and polarization of MDSC by up-regulating the expression of Let-7e

JiangSu Province Natual Science Foundation, Major program, 150 000 RMB

P. I.: Jinping Zhang

  

53Study on novel immune receptors for beta-glucans

Natural Science Foundation of the Jiangsu Higher Education Institutions, 150 000 RMB

P.I.: Xiaoming Gao

  

54The innate recognition and anti viral mechanism of TRIM22 to Hepatitis B virus

JiangSu Province Natual Science Foundation, Major program, 300 000 RMB

P. I.: Sidong Xiong

  

55Tick innate immune signaling and tick-borne-bacterial infection

Jiang Su Province Natural Science Foundation, 200 000 RMB

P.I.: Jianfeng Dai

  

56The role of mir-29b2 in regulating T1/T2 B cell development

Jiang Su Province Natural Science Foundation, 100 000 RMB

P.I.: Jinping Zhang

  

57Identification of glycophingolipids involved in hepatoma metastasis

JiangSu Province Science and Technology program, 80 000 RMB

P. I.: Yunsen Li

  

58Screening of the Host Proteins Interacting with HSV-1 ICP22, and characterization of their Biological functions during Infecton.

Natural Science Foundation of the Jiangsu Higher Education Institutions, 32 000 RMB

Investigator: Shuai Wang

  

59The role and mechanism study of HMGB1 in endoplasmic reticulum stress with viral induced myocarditis

Natural Science Foundation of the Jiangsu Higher Education Institutions, 30 000 RMB

Investigator: Yan Yue

  

60Immunostimulating effect of calreticulin in sera of rheumatoid arthritis patients and the associated molecular mechanisms.

Natural Science Foundation of the Jiangsu Higher Education Institutions, 30 000 RMB

Investigator: Fangyuan Gong

  

61Role of recombinant calreticulin in inhibiting mouse experimental autoimmune encephalomyelitis

JiangSu Province Natual Science Foundation, 30 000 RMB

P.I.: Chao Hong

  

62Development of a novel oral tumor vaccine using Salmonella as a minigene autotransporter carrier

Development Program of Suzhou Administration of Science and technology, 150 000 RMB

P. I.: Haiyan Liu