Principal Investigator
Hui Zheng M.D., Ph.D. Professor of IBMS Professor Hui Zheng received his Bachelor degree in 2001 and Ph.D. degree in 2006 in Xiangya Medical School of Central South University. He received his postdoctoral training in the University of Pennsylvania in America from 2008 to 2013. Professor Hui Zheng is focusing on exploring the broad-spectrum antiviral signaling mechanisms of the body. So far, he has published a series of papers in peer reviewed journals, including Nat Microbiol, Mol Cell, Sci Adv, EMBO Rep, PLoS Pathog, J Immunol, J Biol Chem, etc. Professor Hui Zheng is currently a full professor at the Institutes of Biology and Medical Sciences in Soochow University, and the deputy director of the International Institute of Infection and Immunity of IBMS in Soochow University. Research Interest We are interested in exploring host broad-spectrum antiviral mechanisms, aiming at strengthening host antiviral activity and developing potential antiviral strategies. Currently, we are focusing on three major aspects: (1) To enhance interferon (IFN) antiviral efficacy, and promote antiviral applications of IFN; (2) To identify new antiviral or proviral proteins and uncover their underlying mechanisms; (3) To develop potential antiviral inhibitors and antiviral small interfering peptides (IPs).
Selected publications 1. Guo T, Zuo Y, Qian L, Liu J, Yuan Y, Xu K, Miao Y, Feng Q, Chen X, Jin L, Zhang L, Dong C*, Xiong S*, Zheng H*.ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP. Nature Microbiology. 2019 Nov;4(11):1872-1884. 2. Yuan Y#, Miao Y#, Qian L, Zhang Y, Liu C, Liu J, Zuo Y, Feng Q, Guo T, Zhang L, Chen X, Jin L, Huang F, Zhang H, Zhang W, Li W, Xu G, Zheng H*.Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense. Molecular Cell. 2020 Feb 20;77(4):734-747. 3. Zhang HG#, Wang B#, Yang Y, Liu X, Wang J, Xin N, Li S, Miao Y, Wu Q, Guo T, Yuan Y, Zuo Y, Chen X, Ren T, Dong C, Wang J, Ruan H, Sun M, Xu X*, Zheng H*. Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis. Cell Research. 2022 Jul 12:1-17. (Highlight in Cell Research , 2022, 32:869–870). 4. Zuo Y, He J, Liu S, Xu Y, Liu J, Qiao C, Zang L, Sun W, Yuan Y, Zhang H, Chen X, Jin L, Miao Y, Huang F, Ren T, Wang J, Qian F, Zhu C, Zhang W, Xu G, Ma F, Zheng H*. Lats1 is a central signal transmitter for achieving full type-I interferon activity. Science Advances. 2022 Apr 8;8(14): eabj3887. 5. Zuo Y, Feng Q, Jin L, Huang F, Miao Y, Liu J, Xu Y, Chen X, Zhang H, Guo T, Yuan Y, Zhang L, Wang J, Zheng H*. Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling. Nature Communications. 2020 Mar 2;11(1):1146. 6. Yuan Y#, Miao Y#, Ren T#, Huang F, Qian L, Chen X, Zuo Y, Zhang HG, He J, Qiao C, Du Q, Wu Q, Zhang W, Zhu C, Xu Y, Wu D, Shi W, Jiang J, Xu G, Zheng H*. High salt activates p97 to reduce host antiviral immunity by restricting Viperin induction. EMBO Reports. 2021 Nov 15:e53466. 7. Liu J#, Jin L#, Chen X, Yuan Y, Zuo Y, Miao Y, Feng Q, Zhang H, Huang F, Guo T, Zhang L, Zhu L, Qian F, Zhu C,Zheng H*. USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity. PLoS Pathogens. 2020 Jan 3;16(1):e1008215. 8. Zhang L, Liu J, Qian L, Feng Q, Wang X, Yuan Y, Zuo Y, Cheng Q, Miao Y, Guo T, Zheng X, Zheng H*. Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome. PLoS Pathogens. 2018 May 7;14(5):e1007067. 9. Feng Q#, Miao Y#, Ge J#, Yuan Y#, ZuoY, QianL, Liu J, Cheng Q, Guo T, ZhangL, YuZ*, Zheng H*. ATXN3 positively regulates type I-IFN antiviral response by deubiquitinating and stabilizing HDAC3. J Immunol. 2018 Jul 15;201(2):675-687. 10. Ren Y#, Zhao P#, Liu J, Yuan Y, Cheng Q, Zuo Y, Qian L, Liu C, Guo T, Zhang L, Wang X, Qian G, Li L, Ge J, Dai J, Xiong S*, Zheng H*. Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus. PLoS Pathogens. 2016 Jul 19;12(7):e1005764. 11. Li L#, Qian G#, Zuo Y, Yuan Y, Cheng Q, Guo T, Liu J, Liu C, Zhang L, Zheng H*. Ubiquitin-dependent Turnover of ADAR1 is Required for Efficient Antiviral Activity of Type I-interferon. J Biol Chem. 2016 Nov 25;291(48):24974-24985.
E-mail：Huizheng@suda.edu.cn Office：Dushu Lake 703-B410 Office Tel：(86)512 658 83505 |
