课题组负责人
温振科博士，博导
苏州大学特聘教授
生物医学研究院执行院长
温振科博士，山东人；2004年毕业于山东第一医科大学、获临床医学学士学位，2007年毕业于复旦大学上海医学院、师从熊思东教授获免疫学硕士学位，2007-2010年在青岛市中心血站输血医学研究所任医师、副所长，随即在复旦大学上海医学院师从熊思东教授攻读免疫学博士学位，2013年博士毕业后在美国西奈山医学院和斯坦福大学做Postdoc和Research Scientist；2019年9月加盟苏州大学IBMS任教授、课题组长，荣获国家海外高层次人才青年项目、江苏特聘教授、江苏省杰青和姑苏创新创业领军人才；现任IBMS执行院长、江苏省感染与免疫重点实验室主任。
研究方向
核酸抗原适应性免疫是尚未解决的免疫学基本科学问题。
我们聚焦核酸抗原—自身DNA的适应性免疫，依托临床患者与对照人群队列、人源化疾病模型、人源组织类器官和疾病相关细胞互作平台，深入研究：
（1）自身DNA适应性免疫识别与应答的细胞和分子基础；
（2）自身DNA调控T/B细胞分化与功能的分子机制及其干预；
（3）自身DNA重塑组织器官区域免疫特性的作用基础及应对策略。
近期主要成果（*Co-first, #Corresponding）
1. Hu C, Qiao W, Li X, Ning ZK, Liu J, Dalangood S, Li H, Yu X, Zong Z#,Wen Z#, Gui J#. Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells. Cell Metab 2024 Jan 23:S1550-4131(24)00006-8.
2. Wang Y, Liu M, Zhang L, Liu X, Ji H, Wang Y, Gui J#, Yue Y#, Wen Z#. Cancer CD39 drives metabolic adaption and mal-differentiation of CD4+ T cells in patients with non-small-cell lung cancer. Cell Death Dis 2023; 14(12):804.
3. Qiao W, Hu C, Ma J, Dong X, Dalangood S, Li H, Yuan C, Lu B, Gao WQ, Wen Z#, Yin W#, Gui J#. Low-dose metronomic chemotherapy triggers oxidized mtDNA sensing inside tumor cells to potentiate CD8+T anti-tumor immunity. Cancer Lett 2023; 216370.
4. Liu Z, Lei J, Wu T, Hu W, Zheng M, Wang Y, Song J, Ruan H, Xu L, Ren T#, Xu W#, Wen Z#. Lipogenesis promotes mitochondrial fusion and maintains cancer stemness in human NSCLC. JCI Insight 2023; 8(6):e158429.
5. Liu Z, Shan S, Yuan Z, Wu F, Zheng M, Wang Y, Gui J, Xu W, Wang C#, Ren T#, Wen Z#. Mitophagy bridges DNA sensing with metabolic adaption to expand lung cancer stem-like cells. EMBO Rep 2023; 24(2):e54006.
6. Jiang W, Sun M, Wang Y, Zheng M, Yuan Z, Mai S, Zhang X, Tang L, Liu X#, Wang C#, Wen Z#. Critical Role of Notch-1 in Mechanistic Target of Rapamycin Hyperactivity and Vascular Inflammation in Patients With Takayasu Arteritis. Arthritis Rheumatol 2022; 74(7):1235-1244.
7. Wen Z#, Xu L, Xu W, Xiong S#. Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt Licenses the Differentiation and Function of a Unique Subset of Follicular Helper T Cells in Response to Immunogenic Self-DNA in Systemic Lupus Erythematosus. Arthritis Rheumatol 2021; 73(8):1489-1500.
8. Jin K, Wen Z, Wu B, Zhang H, Qiu J, Wang Y, Warrington KJ, Berry GJ, Goronzy JJ, Weyand CM. NOTCH-induced rerouting of endosomal trafficking disables regulatory T cells in vasculitis. J Clin Invest 2021; 131(1):e136042.
9. Zhang J, Zhao L, Wang J, Cheng Z, Sun M, Zhao J, Liu B, Liu X#, Wen Z#, Li Z#. Targeting Mechanistic Target of Rapamycin Complex 1 Restricts Proinflammatory T Cell Differentiation and Ameliorates Takayasu Arteritis. Arthritis Rheumatol 2020; 72(2):303-315.
10. Li Y, Shen Y, Jin K, Wen Z, Cao W, Wu B, Wen R, Tian L, Berry GJ, Goronzy JJ, Weyand CM. The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation. Cell Metab 2019; 30(3):477-492.
11. Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, Tian L, Shoor S, Roche NE, Goronzy JJ, Weyand CM. N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation. Nat Immunol 2019; 20:313-325.
12. Wen Z, Shen Y, Berry G, Shahram F, Li Y, Watanabe R, Liao YJ, Goronzy JJ, Weyand CM. The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway. Sci Transl Med 2017; 9(399). pii: eaal3322.
13. Shen Y, Wen Z, Li Y, Matteson EL, Hong J, Goronzy JJ, Weyand CM. Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells. Nat Immunol 2017; 18(9):1025-1034.
14. Wen Z*, Shimojima Y*, Shirai T, Li Y, Ju J, Yang Z, Tian L, Goronzy JJ, Weyand CM. NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs. J Clin Invest 2016; 126:1953-67.
15. Li Y, Shen Y, Hohensinner P, Ju J, Wen Z, Goodman SB, Zhang H, Goronzy JJ, Weyand CM. Deficient activity of the nuclease MRE11A induces T cell aging and promotes arthritogenic effector functions in patients with rheumatoid arthritis. Immunity 2016; 45:903-916.
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