课题组负责人

熊思东 博士

苏州大学特聘教授

生物医学研究院院长

苏州大学 校长

熊思东教授,1992年在复旦大学(原上海医科大学)获医学博士学位后,曾在法国国立卫生与健康研究院(INSERM)、美国加州大学(UCSD)作博士后和访问学者。曾任复旦大学研究生院副院长、复旦学院院长、免疫生物学研究所所长、上海基因免疫与疫苗研究中心主任、卫生部分子病毒学重点实验室副主任。熊思东教授2009年加盟苏州大学,被聘为特聘教授,同时任苏州大学副校长、苏州大学生物医学研究院院长,现任苏州大学校长。熊思东教授的学术兴趣为分子免疫学和病毒学研究,作为课题负责人主持了国家自然基金重大项目、国家“十二五”、“十一五”传染病重大专项、国家863项目、国家973子课题、上海市重大项目、上海市科委重点项目、江苏省攀登计划项目、江苏省自然基金重大项目等项目的研究。先后在Nature Biotechnology、PNAS、Hepatology、J Virol、J Immunol、Faseb J、Cell Death Differ等学术期刊等发表论文300余篇,申请国家发明专利32项,主编、副主编学术专著14本,参编教材22部。同时曾作为创院院长创建了我国第一个本科生院意义的复旦学院,开国内通识教育之先河,在国内外教育界引起广泛反响。


研究方向

1、感染免疫

感染免疫是研究宿主和病原微生物相互作用的科学,研究病原微生物的免疫逃避和宿主防卫是该领域的方向之一。一方面人类通过固有和获得性免疫系统来抵抗外界微生物的入侵,而另外一个方面病原微生物可能在共同进化过程中利用这个系统来繁殖后代。我们聚焦于柯萨奇病毒B3、乙型肝炎病毒和分支结核杆菌这三类在我国引起重要公共健康问题的病原体进行研究。研究内容包括:动物感染模型的建立、鉴定病原体毒力因子或宿主感受器、分子病理机制研究、新型黏膜疫苗或者治疗策略的设计等。通过这些研究我们期望能够更好的阐述感染性疾病的致病病理机制,同时提供有效的治疗手段。

2、自身免疫性疾病

自身免疫是指机体因未能识别自我构成成分而引起的对自身內源分子,细胞和组织产生的免疫反应。而由此产生的异常免疫应答则会导致自身免疫性疾病。系统性红斑狼疮(SLE)是一种复杂的自身免疫病。病人对自身细胞核内的某些抗原失去免疫耐受,产生致病性的自身抗体,形成抗原-抗体免疫复合物,在多个器官中沉积并导致损伤。该病的病因涉及多种遗传和环境因素,具有很高的多样性。全基因组相关性研究和动物模型,临床数据表明,SLE的病因主要和以下三种免疫途径相关:1、细胞碎片和免疫复合体的清除;2、固有免疫的激活(TLR IIFN介导的炎症反应);3T/B淋巴细胞的激活(过量的淋巴细胞克隆扩增及B细胞免疫耐受缺陷)。当前SLE的研究热点包括免疫反应的细胞调控机制;表观遗传因素和微小RNA对红斑狼疮易感基因表达的调控;筛选能够反映疾病预测及预后风险的的高敏感高特异性生物标志物;及特异性的治疗方法。


课题组成员

董春升博士,副教授,硕导

董春升博士于2006年获得中国科学院武汉病毒研究所微生物学博士学位。之后在美国威斯康星医学院和耶鲁医学院从事博士后研究,2011年加入苏州大学生物医学研究院担任熊思东课题组特聘副教授职位。董春升博士的研究方向包括:1、感染免疫;2、病原体与宿主相互作用;3、病毒疫苗的研发。迄今为止已在其相关领域发表近30篇高水平研究性论文。


董元舒博士, 副教授,硕导

董元舒博士于2001年在美国University of Alabama at Birmingham获得细胞学博士学位,其后在The Wistar Institute 做博士后研究。20052012年先后在George Mason University Indiana University 担任助理研究教授。2013年加入苏州大学生物医学研究院担任熊思东课题组特聘副教授职位。董元舒博士的研究方向包括:1、结核分枝杆菌感染人体各阶段的生物标志物及其免疫逃逸的分子机制;2、自噬在自身免疫病发生和发展中的作用。

 

岳艳博士,副教授

岳艳博士于2009年获得复旦大学免疫学博士学位。2010年加入苏州大学生物医学研究院担任熊思东课题组讲师,2013年晋升副教授。岳艳博士的研究方向包括CVB3诱发的病毒性心肌炎的分子病理机制及防治策略研究,高效粘膜疫苗递送系统及新型抗感染疫苗的开发。迄今为止已在其相关领域发表20余篇高水平研究性论文并多次在国内国际会议上作学术报告。

齐兴梅博士,副教授

齐兴梅博士于2011年获得东华大学生物化学与分子生物学博士学位,并于2008-2010年期间作为联合培养博士生赴加拿大Dalhousie大学医学院学习两年,研究方向为蛋白质内含子及其介导的蛋白质剪接。2012年加入苏州大学生物医学研究院担任熊思东课题组讲师,2016年晋升副教授。目前研究方向涉及病毒性疾病及自身免疫性疾病等方面。

胡静平硕士,技术员

胡静平于2010年获得苏州大学微生物专业硕士学位。同年加入苏州大学生物医学研究院担任技术员。主要从事抗炎免疫及单克隆抗体治疗的研究。




 

近五年发表SCI论文

  1. Zhang H, Yue Y, Sun T, Wu X, Xiong S. Transmissible endoplasmic reticulum stress from myocardiocytes to macrophages is pivotal for the pathogenesis of CVB3-induced viral myocarditis. Scientific reports. Feb 08 2017;7:42162.

  2. Qi X, Xiong S. Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis. Scientific reports. Feb 02 2017;7:41485.

  3. Fan X, Yue Y, Xiong S. Incorporation of a bi-functional protein FimH enhances the immunoprotection of chitosan-pVP1 vaccine against coxsackievirus B3-induced myocarditis. Antiviral research. Jan 28 2017;140:121-132.

  4. Wang C, Dong C, Xiong S. IL-33 enhances macrophage M2 polarization and protects mice from CVB3-induced viral myocarditis. Journal of molecular and cellular cardiology. Dec 29 2016;103:22-30.

  5. Dong N, Dong C, Xiong S. Janus effects of ADAR1 on CVB3-induced viral myocarditis at different infection stages. International journal of cardiology. Nov 15 2016;223:898-905. 2IF:4.638

  6. Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, Qian L, Liu C, Guo T, Zhang L, Wang X, Qian G, Li L, Ge J, Dai J, Xiong S#, Zheng H#. Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus. PLoS pathogens. Jul 2016;12(7):e1005764.

  7. Lu M, Xu W, Gao B, Xiong S. Blunting Autoantigen-induced FOXO3a Protein Phosphorylation and Degradation Is a Novel Pathway of Glucocorticoids for the Treatment of Systemic Lupus Erythematosus. Journal of biological chemistry. Sep 16 2016;291(38):19900-19912.

  8. Su N, Yue Y, Xiong S: Monocytic myeloid-derived suppressor cells from females, but not males, alleviate CVB3-induced myocarditis by increasing regulatory and CD4(+)IL-10(+) T cells. Scientific reports. 2016;6:22658.

  9. Lu M, Yu S, Xu W, Gao B, Xiong S: HMGB1 Promotes Systemic Lupus Erythematosus by Enhancing Macrophage Inflammatory Response.Journal of immunology research 2015, 2015:946748.

  10. Zha X, Yue Y, Dong N, Xiong S: Endoplasmic Reticulum Stress Aggravates Viral Myocarditis by Raising Inflammation Through the IRE1-Associated NF-kappaB Pathway. Canadian journal of cardiology 2015, 31(8):1032-1040.

  11. Qi X, Sun Y, Xiong S: A single freeze-thawing cycle for highly efficient solubilization of inclusion body proteins and its refolding into bioactive form. Microbial cell factories 2015, 14:24.

  12. Chai D, Yue Y, Xu W, Dong C, Xiong S: AIM2 co-immunization favors specific multifunctional CD8(+) T cell induction and ameliorates coxsackievirus B3-induced chronic myocarditis. Antiviral research 2015, 119:68-77.

  13. Dong C, Qu L, Wang H, Wei L, Dong Y, Xiong S: Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication. Antiviral research 2015, 118:110-117.

  14. Gui J, Chen R, Xu W, Xiong S: Remission of CVB3-induced myocarditis with Astragaloside IV treatment requires A20 (TNFAIP3) up-regulation. Journal of cellular and molecular medicine 2015, 19(4):850-864.

  15. Song T, Dong C, Xiong S: Signaling lymphocyte-activation molecule SLAMF1 augments mycobacteria BCG-induced inflammatory response and facilitates bacterial clearance. International journal of medical microbiology : IJMM 2015, 305(6):572-580.

  16. Zhong L, Hu J, Shu W, Gao B, Xiong S: Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication. Cell death & disease2015, 6:e1770.

  17. Zhou L, He X, Gao B, Xiong S: Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis. Journal of virology 2015, 89(20):10512-10523.

  18. Zhang R, Wang K, Ping X, Yu W, Qian Z, Xiong S#, Sun B#: The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and Pathogenesis. Journal of virology2015, 89(22):11383-11395.

  19. Zhang Y, Li W, Li L, Li Y, Fu R, Zhu Y, Li J, Zhou Y, Xiong S#, Zhang H#: Structural Damage in the C. elegans Epidermis Causes Release of STA-2 and Induction of an Innate Immune Response. Immunity 2015, 42(2):309-320.

  20. Ye T, Yue Y, Fan X, Dong C, Xu W, Xiong S: M cell-targeting strategy facilitates mucosal immune response and enhances protection against CVB3-induced viral myocarditis elicited by chitosan-DNA vaccine. Vaccine 2014, 32(35):4457-4465.

  21. Xiao P, Dong C, Yue Y, Xiong S: Dynamic expression of microRNAs in M2b polarized macrophages associated with systemic lupus erythematosus. Gene 2014, 547(2):300-309.

  22. Wen Z, Xu L, Xu W, Xiong S: Detection of dynamic frequencies of Th17 cells and their associations with clinical parameters in patients with systemic lupus erythematosus receiving standard therapy. Clin Rheumatol 2014, 33(10):1451-1458.

  23. Wang Y, Gao B, Xiong S: Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis. American journal of physiology Heart and circulatory physiology 2014, 307(10):H1438-1447.

  24. Liu L, Yue Y, Xiong S: NK-derived IFN-gamma/IL-4 triggers the sexually disparate polarization of macrophages in CVB3-induced myocarditis. J Mol Cell Cardiol 2014, 76C:15-25.

  25. Li B, Yue Y, Dong C, Shi Y, Xiong S: Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production. Clin Exp Rheumatol 2014, 32(5):705-714.

  26. Kong H, Dong C, Xiong S: A novel vaccine p846 encoding Rv3615c, Mtb10.4, and Rv2660c elicits robust immune response and alleviates lung injury induced by Mycobacterium infection. Hum Vaccin Immunother 2014, 10(2):378-390.

  27. Hu Y, Dong C, Yue Y, Xiong S: In vivo delivery of interleukin-35 relieves coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells. Arch Virol 2014, 159(9):2411-2419.

  28. Chai D, Yue Y, Xu W, Dong C, Xiong S: Mucosal co-immunization with AIM2 enhances protective SIgA response and increases prophylactic efficacy of chitosan-DNA vaccine against coxsackievirus B3-induced myocarditis. Hum Vaccin Immunother 2014, 10(5):1284-1294.

  29. Zhang W, Zhou Q, Xu W, Cai Y, Yin Z, Gao X, Xiong S: DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. The Journal of biological chemistry 2013, 288(19):13534-13550.

  30. Zhang W, Cai Y, Xu W, Yin Z, Gao X, Xiong S: AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation. Journal of clinical immunology 2013, 33(5):925-937.

  31. Wen Z, Xu L, Xu W, Yin Z, Gao X, Xiong S: Interleukin-17 expression positively correlates with disease severity of lupus nephritis by increasing anti-double-stranded DNA antibody production in a lupus model induced by activated lymphocyte derived DNA. PloS one 2013, 8(3):e58161.

  32. Wen Z, Xu L, Chen X, Xu W, Yin Z, Gao X, Xiong S: Autoantibody induction by DNA-containing immune complexes requires HMGB1 with the TLR2/microRNA-155 pathway. Journal of immunology 2013, 190(11):5411-5422.

  33. Li Z, Yue Y, Xiong S: Distinct Th17 inductions contribute to the gender bias in CVB3-induced myocarditis. Cardiovasc Pathol 2013, 22(5):373-382.

  34. Gao B, Xu W, Zhong L, Zhang Q, Su Y, Xiong S: p300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression independently of its histone acetyltransferase activity. European journal of immunology 2013, 43(8):2174-2184.

  35. Gao B, Xu W, Wang Y, Zhong L, Xiong S: Induction of TRIM22 by IFN-gamma Involves JAK and PC-PLC/PKC, but Not MAPKs and pI3K/Akt/mTOR Pathways. J Interferon Cytokine Res 2013, 33(10):578-587.

  36. Gao B, Wang Y, Xu W, Li S, Li Q, Xiong S: Inhibition of histone deacetylase activity suppresses IFN-gamma induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. Journal of immunology 2013, 191(1):464-471.

  37. Dong C, Zhao G, Zhong M, Yue Y, Wu L, Xiong S: RNA sequencing and transcriptomal analysis of human monocyte to macrophage differentiation. Gene 2013, 519(2):279-287.

 

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