课题负责人

  

刘合宾博士 特聘教授 博导


刘合宾博士,2004年获浙江大学医学院附属第一医院传染病研究所医学博士学位 (传染病学专业),2005年获瑞典于默奥(Umeå)大学哲学博士(医学分子生物学专业)。2005-2006年伦敦帝国理工学院分子免疫系博士后、2006-2012年剑桥大学病理系博士后、Senior Investigator。先后在西交利物浦大学生物科学系任助理教授、副教授(tenured)、PI、博士生导师。现为苏州大学生物医学研究院特聘教授、PI、博导。在Mol CellPNASJ Immunol等发表多篇高水平SCI研究论文。

  

主要研究方向:T细胞免疫调控及RNA病毒感染模型与免疫逃逸机制, 包括:

1、细胞核孔复合体 (Nuclear Pore Complex, NPC)T 细胞激活过程中的功能和调控作用;

2GITR共刺激受体信号转导与T 细胞免疫调控;

3、免疫接头蛋白(immune adaptor) 类泛素化 (Sumoylation)调控T细胞免疫粘附、迁徙及归巢作用机制;

4、免疫接头蛋白调控RNA病毒感染免疫细胞模型与免疫逃逸模型机制。

  

代表性论文 

1. Xiong Y, Yi Y, Wang Y, Yang N, Rudd CE and Liu H* Ubc9 interacts with and SUMOylates the TCR adaptor SLP-76 for NFAT transcription in T cells. J Immunol 2019 Dec 1;203(11):3023-3036.

2. Ye C, Yu Z, Xiong Y, Wang Y, Ruan Y, Guo Y, Chen M, Luan S, Zhang E, and Liu H*, STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction. FASEB J. 2019 Jan;33 (1):286-30

3. Xiong Y, Ye C, Yang N, Li M, and Liu H*, Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion. J Immunol 2017, 199: 4142-4154

4. Ye C, Wang Y, Zhang E, Han X, Yu Z, and Liu H*, VP1 and VP3 are required and sufficient for translation initiation of uncapped IBDV genomic dsRNA. J Virol. 2018 Jan 2;92(2): e01345-17.

5. Ye C, Han X, Yu Z, Zhang E, Wang L, and Liu H*, Infectious Bursal Disease Virus Activates c-Src To Promote alpha4beta1 Integrin-Dependent Viral Entry by Modulating the Downstream Akt-RhoA GTPase-Actin Rearrangement Cascade. J Virol. 2017 Jan 18; 91(3): e01891-16.

6. Liu H*, Thaker YR, Stagg L, Schneider H, Ladbury JE and Rudd CE*, SLP-76 sterile alpha motif (SAM) and individual H5 alpha helix mediate oligomer formation for microclusters and T-cell activation. J Biol Chem 2013, 288(41): 29539-29549.

7. Liu H, Schneider H, Recino A, Richardson C, Goldberg MW, and Rudd CE, The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells. Mol Cell 2015, 59(5): 840-849 faculty 1000特评).

8. Liu H, Purbhoo MA, Davis DM, and Rudd CE, SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering. Proc Natl Acad Sci U S A 2010, 107(22): 10166-10171

9. Purbhoo MA, Liu H, Oddos S, Owen DM, Neil MA, Pageon SV, French PM, Rudd CE, and Davis DM, Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse. Science (Signal) 2010, 3(121): ra36 (T 细胞 LAT 激活的重要模型之一,特评)