课题组负责人

郑慧博士,博导

苏州大学特聘教授

郑慧教授,2001年和2006年分别获得中南大学湘雅医学院医学学士学位和博士学位2008-2013年在美国宾夕法尼亚大学从事博士后工作。20131月加入苏州大学生物医学研究院,任职特聘教授目前入选国家海外高层次青年人才、江苏省“高层次海外引进创新创业”人才、江苏省杰出青年、江苏省“六大人才高峰计划”人才,苏州市紧缺高层次人才等。独立开展工作以来,以主要通讯(独立或末位通讯)作者在国际高水平期刊发表了一系列研究论文,包括Nature Microbiology, Molecular Cell, Cell Research, Science Advances, Nature Communications, EMBO Reports, PLoS Pathogens (3篇:201620182020)J ImmunolJ Biol Chem等。相关成果获得了国际免疫学、病原学领域专家的高度关注和好评

  

研究方向

我们的研究兴趣是机体的广谱抗病毒机制。通过揭示机体多样性的抗病毒信号,发掘机体的抗病毒潜能,旨在发展出广谱抗病毒策略。目前,我们的研究焦点包括三个方面:(1)提升先天抗病毒细胞因子干扰素 (Interferon, IFN) 的抗病毒功效以及拓展IFN广谱抗病毒应用;(2)鉴定具有广谱抗病毒或促病毒活性的宿主蛋白,并揭示其调控病毒感染的机制;(3)发展潜在的抗病毒小分子抑制剂和干扰肽。

  

代表性论文


1. Guo T, Zuo Y, Qian L, Liu J, Yuan Y, Xu K, Miao Y, Feng Q, Chen X, Jin L, Zhang L, Dong C*, Xiong S*, Zheng H*. ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP. Nature Microbiology2019 Nov;4(11):1872-1884.

     (Invited Scientific Blogs by Nature Microbiology Community: “behind the paper”)  

https://naturemicrobiologycommunity.nature.com/posts/48116-exploiting-ifns-antiviral-efficacy-to-fight-a-broad- spectrum-of-viruses

2. Yuan Y#, Miao Y#, Qian L, Zhang Y, Liu C, Liu J, Zuo Y, Feng Q, Guo T, Zhang L, Chen X, Jin L, Huang F, Zhang H, Zhang W, Li W, Xu G, Zheng H*.Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense. Molecular Cell. 2020 Feb 20;77(4):734-747.

   (News & ViewsEMBO Rep. 2022 Jan 5;23(1): e54258)

 https://www.embopress.org/doi/epdf/10.15252/embr.202154258

3.  Zhang HG#, Wang B#, Yang Y, Liu X, Wang J, Xin N, Li S, Miao Y, Wu Q, Guo T, Yuan Y, Zuo Y, Chen X, Ren T, Dong C, Wang J, Ruan H, Sun M, Xu X*Zheng H*. Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis. Cell Research. 2022 Oct;32(10):897-913.

     (Highlight in Cell Research , 2022, 32:869–870). 

     (“EDITORS' CHOICE” by Science Signaling: “Innate depression”).

 https://www.science.org/doi/10.1126/scisignal.ade4885

4. Zuo Y, He J, Liu S, Xu Y, Liu J, Qiao C, Zang L, Sun W, Yuan Y, Zhang H, Chen X, Jin L, Miao Y, Huang F, Ren T, Wang J, Qian F, Zhu C, Zhang W, Xu G, Ma F, Zheng H*. Lats1 is a central signal transmitter for achieving full type-I interferon activity. Science Advances. 2022 Apr 8;8(14): eabj3887.

5. Zuo Y, Feng Q, Jin L, Huang F, Miao Y, Liu J, Xu Y, Chen X, Zhang H, Guo T, Yuan Y, Zhang L, Wang J, Zheng H*. Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling. Nature Communications. 2020 Mar 2;11(1):1146.

6. Yuan Y#, Miao Y#, Ren T#, Huang F, Qian L, Chen X, Zuo Y, Zhang HG, He J, Qiao C, Du Q, Wu Q, Zhang W, Zhu C, Xu Y, Wu D, Shi W, Jiang J, Xu G, Zheng H*. High salt activates p97 to reduce host antiviral immunity by restricting Viperin induction. EMBO Reports. 2021 Nov 15:e53466. 

   (News & Views: EMBO Rep. 2022 Jan 5;23(1): e54258)

 https://www.embopress.org/doi/epdf/10.15252/embr.202154258

7. Liu J#, Jin L#, Chen X, Yuan Y, Zuo Y, Miao Y, Feng Q, Zhang H, Huang F, Guo T, Zhang L, Zhu L, Qian F, Zhu C,Zheng H*. USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity. PLoS Pathogens. 2020 Jan 3;16(1):e1008215. 

8. Zhang L, Liu J, Qian L, Feng Q, Wang X, Yuan Y, Zuo Y, Cheng Q, Miao Y, Guo T, Zheng X, Zheng H*Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome. PLoS Pathogens. 2018 May 7;14(5):e1007067. 

9. Feng Q#, Miao Y#, Ge J#, Yuan Y#, ZuoY, QianL, Liu J, Cheng Q, Guo T, ZhangL, YuZ*, Zheng H*. ATXN3 positively regulates type I-IFN antiviral response by deubiquitinating and stabilizing HDAC3. J Immunol. 2018 Jul 15;201(2):675-687.

   Selected as “Highlight In This Issue” by J Immunol 2018; 201:323-324

10.  Ren Y#, Zhao P#, Liu J, Yuan Y, Cheng Q, Zuo Y, Qian L, Liu C, Guo T, Zhang L, Wang X, Qian G, Li L, Ge J, Dai J, Xiong S*, Zheng H*. Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus. PLoS Pathogens. 2016 Jul 19;12(7):e1005764.

11. Li L#, Qian G#, Zuo Y, Yuan Y, Cheng Q, Guo T, Liu J, Liu C, Zhang L, Zheng H*. Ubiquitin-dependent Turnover of ADAR1 is Required for Efficient Antiviral Activity of Type I-interferon. J Biol Chem. 2016 Nov 25;291(48):24974-24985.

  

课题组现有师资


袁玉康博士,副教授

袁玉康于2013年获得临沂大学学士学位,同年考入苏州大学硕博连读。2018年入职苏州大学生物医学研究院师资博后,2021年聘为副教授,2022年获得苏州大学优秀青年学者。其研究兴趣主要是干扰素诱导基因调控对干扰素抗病毒功能的影响

  


左宜波博士,讲师

左宜波于2015年获得齐鲁工业大学学士学位,同年考入苏州大学硕博连读。2020年入职苏州大学生物医学研究院师资博后。其研究兴趣主要是代谢与IFNs抗病毒活性调控

 

牛精铃硕士,科研助理

牛精铃于2020年毕业于河南科技大学医学院药理学专业并获得硕士学位。2021年入职苏州大学生物医学研究院,任技术员。


课题组照片

  

  

  


 

    

E-mailhuizheng@suda.edu.cn

办公电话:(86)512 65883505