题组负责人


周芳芳博士 特聘教授 博导


周芳芳教授,2008年毕业于清华大学生物科学与技术系并获博士学位。2008-2013年在荷兰莱顿大学医学中心先后任职博士后、研究员。2013-2014年在荷兰莱顿大学医学中心任研究助理教授。201410月受聘苏州大学生物医学研究院特聘教授及博士生导师,2017年入选长江青年学者。周芳芳教授长期致力于固有免疫响应的分子机制研究,取得了多项科研成果。独立开展工作以后以通讯作者(含共同)在国际著名期刊如Nature Immunology(两篇)、Nature Cell Biology(两篇)、Molecular Cell(两篇)、Nature CommunicationsTrends in Biochemical SciencesAdvanced Science(三篇)、Signal Transduction and Targeted Therapy(三篇)、Molecular CancerCell Death & DifferentiationProtein CellCancer ResearchCell & Molecular Immunology(两篇)、Frontiers in ImmunologyAdvanced BiosystemsCancer letters等发表论文30余篇。

 

主要研究方向:


1. 固有免疫响应的分子机制和生理、病理调控;

2. 固有免疫防御病毒的机制及干预策略;

3. 肿瘤逃脱固有免疫监视的分子机制;


 

代表性论文*Corresponding author:

1. Wang S, Dai T, Qin Z, Pan T, et al., Zhou F*. Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity via elevating MAVS activity. Nature Cell Biology. 2021 (in press)

2. Wang B, Dai T, Ren J,et al.,Zhou F*.Protein N-myristoylation: functions and mechanisms in control of innate immunity. Cellular & Molecular Immunology. 2021

3. Zhang Z, Fang X, et al., Zhou F*. Acetylation-dependent deubiquitinase OTUD3 controls MAVS activation in innate antiviral immunity. Molecular Cell. 2020

4. Dong Y, Dai T, Wei Y, et al., Zheng M*, Zhou F*. A systematic review of SARS-CoV-2 vaccine candidates. Signal Transduction and Targeted Therapy. 2020

5. Zhou X, Xie F, Wang L, et al., Zhou F*. The function and clinical application of extracellular
 vesicles in innate immune regulation.
 Cellular Molecular Immunology. 2020

6. Wang S*, Zhou L, et al., Zhou F*. The Crosstalk Between Hippo-YAP Pathway and innate Immunity. Frontiers in Immunology. 2020

7. Xie F, Zhou X, Fang MY, et al.,Zhou F*. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy. Advanced Science. 2019

8. Gao L, Wang L, Dai T, Jin K, Zhang Z, et al.,Zhou F*, Zhang L*. Tumor-derived exosomes antagonize innate antiviral immunity. Nature Immunology. 2018

9. Wang S, et al., Zhang L*, Zhou F*. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation. Nature Immunology. 2017

10. Zhang L*, Xie F, et al., Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death Differentiation. 2017

11. Zong Z, Wei Y, Ren J, et al., Zhou F*. The intersection of COVID-19 and cancer: signaling pathways and treatment implications. Molecular Cancer. 2021

12. Guo H, Zhou L, et al., Zhou F*. Promising immunotherapies against COVID-19. Advanced Therapeutics. 2021

13. Dong Y, Dai T, et al.,Zhou F*. Coronavirus in continuous flux: from SARS-CoV to SARS-CoV-2.  Advanced Science. 2020

14. Zong Z, Zhang Z, et al.,Zhou F*. The functional deubiquitinating enzymes in control of innate antiviral immunity. Advanced Science. 2020

15. Jin K, et al., Zhou F*. An Effective Platform for Cancer Immunotherapy: Pooled Knockin Targeting for Genome Engineering Immunotherapies. Signal Transduction and Targeted Therapy. 2020

16. Cheng Z, Dai T, et al.,Zhou F*. The interaction between cGAS-STING pathway and pathogens. Signal Transduction and Targeted Therapy. 2020

17. Zhou L, Zhang Y, et al.,Zhou F*. A dual role of type I interferons in antitumor immunity. Advanced Biosystems. 2020

18. Xie F, Jin K, Shao L, et al., Zhou F*, Zhang L*. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nature Communications. 2017

19. Li Y, et al., Zhou F*, Zhang L*. c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway. Cancer Research. 2016

20. Zhang J, et al., Zhang L*, Zhou F*. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell. 2014

21. Zhang L*,Zhou F*, ten Dijke P*. (2013) Signaling interplay between transforming growthfactor-β receptor and PI3K/AKT pathways in cancer. Trends in Biochemical Sciences. 2013

22. Zhang L,Zhou F*, et al., Ten Dijke P*. TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Molecular Cell. 2013

23. Zhang L, Zhou F*, et al., ten Dijke P*. (2012) USP4is regulated by Akt phosphorylation and directly deubiquitinates TGF-β type Ireceptor. Nature Cell Biology. 2012

24. Zhang L,Zhou F*, et al., Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation. Molecular Biology of the Cell. 2011

 

E-mail: zhoufangfang@suda.edu.cn

OfficeDushu lake 703-B314 


课题组成员

王帅 副研究员 硕导

王帅博士于2010年获得山东大学生物化学与分子生物学博士学位。2010年加中国科学院武汉病毒研究所担任助理研究员职位。2013年加入苏州大学生物医学研究院,目前担任周芳芳课题组副研究员职位。


谢枫 副教授

谢枫于20173月获浙江大学细胞生物学专业博士学位,同年成为周芳芳教授课题组博士后,并获得国家“博新计划”资助。

  



褚峰 助理研究员

褚峰于2014年获得苏州大学发育生物学专业硕士学位,同年加入苏州大学周芳芳教授课题组担任技术员职位。

  

  

  


  

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E-mail: zhoufangfang@suda.edu.cn