题组负责人


周芳芳教授,国家杰青(2021)、长江青年学者(2017)


诚聘博士后,年薪四十万起可晋升。

研究方向:包括但不限于结构生物学、生物信息学、感染、免疫、肿瘤、信号转导等方向。

要求:工作自觉上进、有志于科学研究、有创新思维、甘于寂寞、敢于突破、勇于创造。
有意向者请联系:  zhoufangfang@suda.edu.cn


周芳芳2008年毕业于清华大学生物科学与技术系并获博士学位。2008-2013年在荷兰莱顿大学医学中心先后任职博士后、研究员。2013-2014年在荷兰莱顿大学医学中心任研究助理教授。201410月受聘苏州大学生物医学研究院特聘教授及博士生导师。周芳芳实验室致力于固有免疫响应的分子机制研究,取得了多项科研成果。独立开展工作后以通讯或共同通讯在国内外期刊如Nature Immunology2017, 2018, 2022)、Nature Cell Biology2012, 2021)、Molecular Cell2013, 2020)、Nature Communications (2017, 2022)EMBO Journal (2022)Trends in Biochemical Sciences (2013)Advanced Materials2021)、Advanced Science (2019, 2020a, 2020b, 2021, 2022a, 2022b)Signal Transduction and Targeted Therapy (2020a, 2020b, 2020c, 2021a, 2021b, 2022a, 2022b, 2022c, 2022d)Molecular Cancer (2021)Cell Death & Differentiation (2017)Protein Cell (2014)Cancer Research (2016)Cell & Molecular Immunology (2020, 2021, 2022)Frontiers in Immunology (2021) MBoC2011)等发表论文70余篇。

 

主要研究方向:


1. 固有免疫响应的分子机制和生理、病理调控;

2. 固有免疫防御病毒的机制及干预策略;

3. 肿瘤逃脱固有免疫监视的分子机制;


 

代表性论文*Corresponding author:

1. Breast Cancer Cell-derived Extracellular Vesicles Promote CD8+ T cell Exhaustion via TGF-β type II receptor Signalling. Xie F, Zhou X, et al., Zhang L*, Zhou F*. Nature Communications2022

2. Emerging implications of phase separation in cancer. Ren J, Zhang Z, Zong Z, Zhang L*, Zhou F*Advanced Science. 2022

3. Wang YFang X, Wang S, Wang B, Chu F, Zhang L*, Zhou F*. The role of O-GlcNAcylation in innate immunity and inflammation. Journal of Molecular Cell Biology. 2022

4. Wang B, Zhang L, Zhou F*. Zhang L*. Potential mechanisms by which impaired ketogenesis links metabolism to T-cell dysfunction in patients with severe COVID-19. Medcomm. 2022

5. Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/7 in innate antiviral immunity. Qin Z, Fang X, et al., Zhou F*, Zhang L*. Nature Immunology2022

6. IRF3 and IRF7 require SIRT1 for liquid-liquid phase separation and transactivation of INF-I. Zhou F*, Zhang L*. Nature Immunology (Research Briefing)2022

7. Targeting USP8 inhibits Cancer Progression and Prevents Extracellular-Vesicle TβRII-Induced Exhaustion of CD8+ T cells. Xie F, Zhou X, et al., Zhou F*, Zhang L*. EMBO Journal. 2022

8. Microbiota in tumors: from understanding to application. Xie Y, Xie F, Zhou X, et al., Zhang L*,  Zhou F*. Advanced Science. 2022

9. SARS-CoV-2 Omicron variant: recent progress and future perspectives. Fan Y, Li X, Zhang L, Wan S, Zhang L*,  Zhou F*. Signal Transduction and Targeted Therapy. 2022

10. Cuproptosis: a new form of programmed cell death. Wang Y, Zhang L, Zhou F*. Cellular & Molecular Immunology. 2022

11. Guan J, Zhang L*, Zhou F*. PI3K-PANK4: a new target for de novo synthesis of coenzyme A. Molecular Biomedicine. 2022

12. Wei X, Xie F, Zhou X, Yan H, Liu T, Huang J*, Wang F*, Zhou F*, Zhang L*. Developments in the understanding of pyroptosis and its potential role in the treatment of inflammation and cancer. Cellular & Molecular Immunology. 2022

13. SUMOylation in Viral Replication and Antiviral Defense. Fan Y, Li X, Zhang L,et al., Zhang L*,  Zhou F*. Advanced Science. 2022

14. STING, a critical contributor to SARS-CoV-2 immunopathology. Li H, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2022

15. Ferroptosis in cancer and cancer immunotherapy. Zhao L, Zhou X, Xie F, Zhang L, et al., Zhou F*, Chen J*, Zhang L*. Cancer Communications. 2022

16. Novel pyroptosis-independent functions of gasdermins. Qin Z, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2022

17. Post-translational modifications in liquid-liquid phase separation: a comprehensive review. Li J, Zhang M, et al., Zhou F*, Zhang L*. Molecular Biomedicine. 2022

18. Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions. Wang B, Zhang L, et al., Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2022

19. ADP-riboxanation: a new pyroptosis evasion strategy. Li H, Zhou F*, Zhang L*. J Mol Cell Biol. 2022

20. Wang S, Dai T, Qin Z, Pan T, et al., Zhou F*. Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity via elevating MAVS activity. Nature Cell Biology. 2021

21. Xie F, Su P, Pan T et al., Zhang L*, Zhou F*. Engineering extracellular vesicles enriched with palmitoylated ACE2 as COVID-19 therapy. Advanced Materials. 2021

22. ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A Review. Zhang M, et al., Zeng L*,  Zhou F*. Front Cell Dev Biol. 2021

23. Wang B, Dai T, Ren J,et al.,Zhou F*.Protein N-myristoylation: functions and mechanisms in control of innate immunity.Cellular & Molecular Immunology. 2021

24. Zong Z, Wei Y, Ren J, et al., Zhou F*. The intersection of COVID-19 and cancer: signaling pathways and treatment implications. Molecular Cancer. 2021

25. Xie Y, Xie F, Zhou F*. Targeted anti-tumor immunotherapy using tumor infiltrating cells. Advanced Science. 2021

26. Dong Y, Dai T, Wang B, Zhou F*. The way of SARS-CoV-2 vaccine development: success and challenges.Signal Transduction and Targeted Therapy.2021

27. Fan Y, Zhang L*, Zhou F*. cGAS-like receptors: new RNA sensors in Drosophila. Signal Transduction and Targeted Therapy.2021

28. Guo H, Zhou L, et al., Zhou F*. Promising immunotherapies against COVID-19. Advanced Therapeutics. 2021

29. Zhang Y, Qin Z, Sun W, Chu F, Zhou F*.Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases.Frontiers in Immunology. 2021 

30. Gao L, Zhou F*.Comprehensive Analysis of RUNX and TGF-β Mediated Regulation of Immune Cell Infiltration in Breast Cancer.Frontiers in Cell and Developmental Biology. 2021

31. Zhang Z, Fang X, et al.Zhou F*. Acetylation-dependent deubiquitinase OTUD3 controls MAVS activation in innate antiviral immunity. Molecular Cell. 2020

32. Dong Y, Dai T, Wei Y, et al., Zheng M*, Zhou F*. A systematic review of SARS-CoV-2 vaccine candidates. Signal Transduction and Targeted Therapy. 2020

33. Zhou X, Xie F, Wang L, et al., Zhou F*. The function and clinical application of extracellular
  vesicles in innate immune regulation. Cellular & Molecular Immunology. 2020

34. Wang S*, Zhou L, et al., Zhou F*. The Crosstalk Between Hippo-YAP Pathway and innate Immunity. Frontiers in Immunology. 2020

35. Dong Y, Dai T, et al.,Zhou F*. Coronavirus in continuous flux: from SARS-CoV to SARS-CoV-2.  Advanced Science. 2020

36. Zong Z, Zhang Z, et al.,Zhou F*. The functional deubiquitinating enzymes in control of innate antiviral immunity. Advanced Science. 2020

37. Jin K, et al., Zhou F*. An Effective Platform for Cancer Immunotherapy: Pooled Knockin Targeting for Genome Engineering Immunotherapies. Signal Transduction and Targeted Therapy. 2020

38. Cheng Z, Dai T, et al.,Zhou F*. The interaction between cGAS-STING pathway and pathogens. Signal Transduction and Targeted Therapy. 2020

39. Zhou L, Zhang Y, et al.,Zhou F*. A dual role of type I interferons in antitumor immunity. Advanced Biosystems. 2020

40. Xie F, Zhou X, Fang MY, et al.,Zhou F*. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy. Advanced Science. 2019

41. Gao L, Wang L, Dai T, Jin K, Zhang Z, et al.,Zhou F*, Zhang L*. Tumor-derived exosomes antagonize innate antiviral immunity. Nature Immunology2018

42. Wang S, et al., Zhang L*, Zhou F*. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation. Nature Immunology. 2017

43. Zhang L*, Xie F, et al., Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death Differentiation. 2017

44. Xie F, Jin K, Shao L, et al., Zhou F*, Zhang L*. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nature Communications. 2017

45. Li Y, et al., Zhou F*, Zhang L*. c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway. Cancer Research. 2016

46. Zhang J, et al., Zhang L*, Zhou F*. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell. 2014

47. Zhang L*,Zhou F*, ten Dijke P*. (2013) Signaling interplay between transforming growthfactor-β receptor and PI3K/AKT pathways in cancer. Trends in Biochemical Sciences. 2013

48. Zhang L,Zhou F*, et al., Ten Dijke P*. TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Molecular Cell2013

49. Zhang L, Zhou F*, et al., ten Dijke P*. (2012) USP4 is regulated by Akt phosphorylation and directly deubiquitinates TGF-β type Ireceptor. Nature Cell Biology. 2012

50.Zhang L,Zhou F*et al., Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation. Molecular Biology of the Cell. 2011


 

E-mail: zhoufangfang@suda.edu.cn

OfficeDushu lake 703-B314 


课题组成员

王帅 副研究员 硕导

王帅博士于2010年获得山东大学生物化学与分子生物学博士学位。2010年加中国科学院武汉病毒研究所担任助理研究员职位。2013年加入苏州大学生物医学研究院,目前担任周芳芳课题组副研究员职位。


谢枫 副教授

谢枫于20173月获浙江大学细胞生物学专业博士学位,同年成为周芳芳教授课题组博士后,并获得国家“博新计划”资助。

  



褚峰 助理研究员

褚峰于2014年获得苏州大学发育生物学专业硕士学位,同年加入苏州大学周芳芳教授课题组担任技术员职位。

  

  

  


  

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E-mail: zhoufangfang@suda.edu.cn