Professor Philipp A. Lang
Director of Molecular Medicine II, Heinrich-Heine University, Düsseldorf, Germany.
Philipp A. Lang got his MD degree in Universität Tübingen, German. He got his postdoctoral training in Nobel Prizer Rolf Zinkernagel’s lab. Now he is a W3 professor of Heinrich-Heine University, Düsseldorf, Germany. His team is focusing on studying the immune responses mediated by HBV or HCV infection.
Selected Publications:
1. Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C,Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. Glutathione Primes T Cell Metabolism for Inflammation.Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019.
2. Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA*, Lang KS*. Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.Nat Commun. 2017 Mar 1;8:14447. doi: 10.1038/ncomms14447. (* indicates shared authorship)
3. Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA,Lang PA, Berman HK, Pugh TJ, Lanier LL, Ohashi PS. A distinct innate lymphoid cell population regulates tumor-associated T cells.Nat Med. 2017 Mar;23(3):368-375. doi: 10.1038/nm.4278. Epub 2017 Feb 6.
4. Gil-Cruz C, Perez-Shibayama C, Onder L, Chai Q, Cupovic J, Cheng HW, Novkovic M,Lang PA, Geuking MB, McCoy KD, Abe S, Cui G, Ikuta K, Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs.Nat Immunol. 2016 Dec;17(12):1388-1396. doi: 10.1038/ni.3566. Epub 2016 Oct 31.
5.Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G,Lang PA, Hartmann P, Knolle PA, Schultze JL. Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.Nat Immunol. 2016 May;17(5):593-603. doi: 10.1038/ni.3399. Epub 2016 Mar 7.
6.Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M*, Lang KS*,Lang PA*. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.J Virol. 2015 May;89(9):4748-59. (* indicates shared authorship)
7.Shaabani N, Honke N, Dolff S, Görg B, Khairnar V, Merches K, Duhan V, Metzger S, Recher M, Barthuber C, Hardt C, Proksch P, Häussinger D, Witzke O,Lang PA*, Lang KS*.IFN-γ licenses CD11b+ cells to induce progression of systemic lupus erythematosus.J Autoimmun. 2015 Jun 19. pii: S0896-8411(15)00078-5. (* indicates shared authorship)
8. Qvartskhava N*,Lang PA*, Görg B, Pozdeev VI, Ortiz MP, Lang KS, Bidmon HJ, Lang E, Leibrock CB, Herebian D, Bode JG, Lang F, Häussinger D. Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase.Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5521-6. (* indicates shared authorship)
9. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J,Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW.Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio.Cell Death Differ. 2015 Apr 17.
10. Warsi J, Hosseinzadeh Z, Elvira B, Pelzl L, Shumilina E, Zhang DE, Lang KS,Lang PA, Lang F. USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2.PLoS One. 2015 Jun 5;10(6):e0129365.
11. Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB,Lang PA, Lang KS. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.Nat Commun. 2015 Feb 18;6:6217.
12. Rahbar R, Lin A, Ghazarian M, Yau HL, Paramathas S,Lang PA, Schildknecht A, Elford AR, Garcia-Batres C, Martin B, Berman HK, Leong WL, McCready DR, Reedijk M, Done SJ, Miller N, Youngson B, Suh WK, Mak TW, Ohashi PS. B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.Cancer Immunol Res. 2015 Feb;3(2):184-95.
13.McIlwain DR, Grusdat M, Pozdeev VI, Xu HC, Shinde P, Reardon C, Hao Z, Beyer M, Bergthaler A, Häussinger D, Nolan GP*, Lang KS*,Lang PA*. T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.Eur J Immunol. 2015 Feb;45(2):418-27.
14.Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS*,Lang PA*. Type I interferon protects antiviral CD8(+) T cells from NK cell cytotoxicity.Immunity. 2014 Jun 19;40(6):949-60. (* indicates shared authorship)
15. Honke N, Shabaani N, Zhang DE, Iliakis G, Xu HC, Häussinger D, Recher M, Löhning M,Lang PA*, Lang KS*.Usp18 driven viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes.PLoS Pathogens 2013 Oct; 9(10):e1003650. doi: 10.1371/journal.ppat.1003650. (* indicates shared authorship)