Principal Investigator

Yunsen Li Ph.D.

Professor of IBMS

ProfessorYunsen Li completed his graduate studies in China Pharmaceutical University in 2002. His post-doctoral training was performed in Shanghai Institute of Materia Medica and later University of New Hampshire, USA. He obtained the position of Assistant investigator at MD Anderson Cancer Center in the year of 2007. Professor Li has dedicated his professional life to the Biotechnology of Glycomics and Lipidomics and development of therapeutic drugs for immune-related diseases. His research group integrated advanced techniques in mass spectrometry, glycobiology and bioinformatics, to address questions related to ligands of NKT cell, glycoconjugates drugs or NDV in relation toviral receptors. He also engaged studies of cancer biology with murine models and discovery of possible biomarkers of malignancy in patient samples. His major academic achievements include 53 publications in peer-reviewed journals and authorized 20 patents. Professor Li is currently principle investigator at the Institutes of Biology and Medical Sciences.

Research Interest

The Glycomics and lipidomics Group is an integrated Biotechnology Research Resource built around advanced techniquesin mass spectrometry, glycobiology and lipidomics function. Central applications at this Group include analysis of ligands of NKT cell, therapeutic Glycoconjugates drugs, NDV in relation to viral receptors, studies of cancer biology with murine models and discovery of possible biomarkers of malignancy in patient samples. Supporting these efforts are developments in analytical protocols, and bioinformatics that have aspirations for automation and high throughput analysis. These broad based activities bring together researchers, teachers and students in biochemistry, chemistry and medicine. 

Selected publications:

1. Zhu J, Wang Y, Yu Y, WangZ, Zhu T, Xu X, Liu H, Hawke D, Zhou D, Li Y. Aberrant fucosylation of glycosphingolipids inhuman hepatocellular carcinoma tissues. Liver Int. 2014 Jan;34(1):147-60.

2. Xu X, Yu Y, Wang Z, ZhuT, Wang Y, Zhu J, Chen Z, He Y, Ju L, Li Y. Mass spectrometry based phospholipidomics of mammalian thymus and leukemia patients: implication for function of iNKT cells.Anal Bioanal Chem. 2013 Jun;405(15):5267-78.

3. Tahiri F, Li Y, Hawke D,Ganiko L, Almeida I, Levery S, Zhou D. Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig organs Usedfor Xenotransplantation: Implications for Natural Killer T-Cell Biology. J Carbohydr Chem. 2013 Jan 1;32(1):44-67.

4. Song W, Delyria ES, ChenJ, Huang W, Lee JS, Mittendorf EA, Ibrahim N, Radvanyi LG, Li Y, Lu H, Xu H,Shi Y, Wang LX, Ross JA, Rodrigues SP, Almeida IC, Yang X, Qu J, Schocker NS,Michael K, Zhou D. MUC1 glycopeptide epitopes predicted by computational glycomics. Int J Oncol. 2012Dec;41(6):1977-84.

5. Puga Yung GL, Li Y,Borsig L, Millard AL, Karpova MB, Zhou D, Seebach JD.Xenotransplantation. Complete absence of the α Galxenoantigen and isoglobotrihexosylceramide in α 1,3galactosyltransferase knock-out pigs. 2012 May-Jun;19(3):196-206

6. Wang Z, Wen L, Ma X, ChenZ, Yu Y, Zhu J, Wang Y, Liu Z, Liu H, Wu D, Zhou D, Li Y. High e­xpression of lactotriaosylceramide, adifferentiation-associated glycosphingolipid, in the bone marrow of acutemyeloid leukemia patients. Glycobiology. 2012 Jul;22(7):930-8.

7. Li YS, Arigi E, EichertH, Levery SB. Mass spectrometry of fluorocarbon-labeled glycosphingolipids. J Mass Spectrom. 2010;45 (5):504-19.

8. Li YS, Thapa P, Hawke D, Kondo Y, Furukawa K, Furukawa K, Hsu FF, Adlercreutz D, Weadge J, Palcic MM,Wang PG, Levery SB, Zhou DP. Immunologic Glycosphingolipidomics and NKT Cell Development in Mouse Thymus. J Proteome Res. 2009;8(6):2740-51.

9. Li YS, Teneberg S, ThapaP, Bendelac A, Levery SB, Zhou DP. Sensitive detection of isoglobo and globo series tetraglycosylceramidesin human thymus by ion trap mass spectrometry. Glycobiology. 2008;18 (2):158-65.

10. Li YS, Zhou D, Xia C,Wang PG, Levery SB. Sensitive quantitation of isoglobotriaosylceramide in the presence of isobaric componentsusing electrospray ionization-ion trap mass spectrometry. Glycobiology. 2008;18 (2):166-76.

Team members

Qing Xie Ph.D.,

Lecturer

Qing Xie completed graduate studies in Department of Chemical and Biological Engineering at Zhejiang University and received her Ph.D. degree in 2008. She served as research associate in State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Zhejiang University from year 2008 to 2012. Her research direction was application mass technique in metabolomics andproteomics. Now she is a lecturer at Institutes of Biology and MedicalSciences, Soochow University and focus on study about the structure and function of tumor-associated glycoconjugate.

Selected publications:

1. Hao, S. R., J. J. Xin, J. S. Lian, Q. Xie, D. Y. Chen,Y. Z. Guo, Y. F. Lu, G. P. Sheng, W. Xu, J. R. Huang, and L. J. Li. 2011. Establishing a metabolomic model for the prognosis of hepatitis B virus-inducedacute-on-chronic liver failure treated with different liver support systems. Metabolomics 7:400-412.

2. Xie, Q., J.Wu, G. Xu, and L. Yang. 2006. Asymmetric reduction of o-chloroacetophenone with Candida pseudotropicalis 104. Biotechnology progress 22:1301-1304.

Yanping Wang Ph.D.,

Technician

Yanping Wang achieved her Doctor degree in Analytical Chemistry from Dalian Institute of Chemical Physics, Chinese Academy of Sciences in 2009. She joined Dr. Yunsen Li's lab in the Institutes of Biology and Medical Sciences as a technician at the same year. Her research interests mainly focus on the abnormal glycosylation of glycolipids and glycoproteins.

E-mail：yunsenli@suda.edu.cn

Office：Dushu lake 703-3430

Office Tel：(86)512 658 80419