Principle Investigator

Sidong Xiong Ph.D.

Chair Professor of IBMS

Director of IBMS


Professor Sidong Xiong received his PhD degree in Microbiology from FuDan University in 1992. He performed his post-doc training at the French National Institute for Health and Medical Research (INSERM) followed by a visiting scholar at University of California-San Diego. He has also served multiple administration positions, such as the Associated Director of the Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Chairman of Immunology Department, Dean of Fudan College,Vice-Dean of the Graduate School, Director of Institute for Immunobiology, Fudan Unviersity. Professor Xiong’s research interests are focused on the studies of anti-infection and anti-tumor immunology, pathogenesis of autoimmune diseases, and development of novel DNA vaccines. He has published more than 280 papers in peer-reviewed journals to date, including Nature Biotechnology, PNAS, Hepatology and Journal of Immunology. Additional acedamic contributions include 26 patent applications, chief editor or associate editors for 12 academic books and 15 textbooks, and numerous National or international awards. Professor Xiong is currently Vice-Chancelor of SooChow University and Director of the Institute of Biology and Medical Sciences.


Research Interests

Mechanisms of immune recognition

Cellular and Molecular defense mechanisms in infectious diseases

Cellular and Molecular basis for autoimmune diseases

Design and application of novel vaccines

  

Selected publications

1.Gao B, Wang Y, Xu W, Li S, Li Q, Xiong S: Inhibition of histone deacetylase activity suppresses IFN-gamma induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. J Immunol2013, 191(1):464-471.

2.Wen Z, Xu L, Chen X, Xu W, Yin Z, Gao X, Xiong S: Autoantibody induction by DNA-containing immune complexes requires HMGB1 with the TLR2/microRNA-155 pathway. J Immunol 2013, 190(11):5411-5422.

3.Zhang W, Zhou Q, Xu W, Cai Y, Yin Z, Gao X, Xiong S: DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. J Biol Chem 2013, 288(19):13534-13550.

4.Gao B, Xu W, Zhong L, Zhang Q, Su Y, Xiong S: p300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 e­xpression independently of its histone acetyltransferase activity. Eur J Immunol2013, 43(8):2174-2184.

5.Cao Y, Xu W, Xiong S: Adoptive transfer of regulatory T cells protects against Coxsackievirus B3-induced cardiac fibrosis. PLoS One 2013, 8(9):e74955.

6.Cai Y, Zhang W, Xiong S: Mannose-binding lectin blunts macrophage polarization and ameliorates lupus nephritis. PLoS One 2013, 8(4):e62465.

7.Chen X, Wen Z, Xu W, Xiong S: Granulin exacerbates lupus nephritis via enhancing macrophage M2b polarization. PLoS One 2013, 8(6):e65542.

8.Wen Z, Xu L, Xu W, Yin Z, Gao X, Xiong S: Interleukin-17 e­xpression positively correlates with disease severity of lupus nephritis by increasing anti-double-stranded DNA antibody production in a lupus model induced by activated lymphocyte derived DNA. PLoS One 2013, 8(3):e58161.

9.Zhang W, Cai Y, Xu W, Yin Z, Gao X, Xiong S: AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation. J Clin Immunol 2013, 33(5):925-937.

10.Gao B, Xu W, Wang Y, Zhong L, Xiong S: Induction of TRIM22 by IFN-gamma Involves JAK and PC-PLC/PKC, but Not MAPKs and pI3K/Akt/mTOR Pathways. J Interferon Cytokine Res 2013, 33(10):578-587.

  

Team members

Chunsheng Dong, Chair associate professor

Yuanshu Dong, Chair associate professor

Yan Yue, Lecturer

Xingmei Qi, Lecturer

Jingping Hu, Technician

Xingjuan Fan, Technician

  

E-mailsdxiong@suda.edu.cn

Office:Dushu lake 703-3314

Office Tel:(86)512 658 81255