Principal Investigator

Jianfeng Dai Ph.D.

Professor of IBMS

Professor JianFeng Dai received his Ph.D. degree in Genetics and Molecular Biology in 2006 at Fudan University. During his successful graduate studies, he published six first-author SCI papers and 20 co-author papers. Professor Dai worked as a postdoctoral research scientist under the guidance of Dr. Erol Fikrig in Yale University School of Medicine, USA, from year 2006 to 2011. Among his academic accomplishments, his discovery in novel vaccine targets for tick-borne diseases attracted international attention. It was reported by New York Times, New Haven Channel 8 and New Haven Register. Professor Dai has published multiple high-quality research findings in leading pathological journals including Cell Host Microbe, PLoS Pathogens and Journal of Virology. He also contributed to several publications in Cell and Nature Immunology. Professor Dai’s current research is focused on the infection and pathogenesis mechanisms of vector-borne pathogens, as well as prevention of tick-borne diseases. Professor Dai is currently principle investigator at the Institutes of Biology and Medical Sciences, Soochow University.


Research Interests

  1. Pathogen-host interaction in vector-borne diseases

  2. Infection and pathogenesis of Flavi viruses

  3. New vaccine strategy against vector-borne diseases


Selected publications

  1. Liu L, Dai J*, Zhao YO, Narasimhan S, et al. The Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of humangranulocytic anaplasmosis, J Infect Dis, 2012 Oct;206(8):1233-41. (IF=6.41) *(Corresponding author; co-first author).

  2. Pan W, Zuo X, Feng T, Shi X, Dai J*. Guanylate-binding protein 1 participates in cellular antiviral response to dengue virus.Virol J.2012 Nov 27;9:292 IF=2.34* (Corresponding author).

  3. Zuo X, Pan W, Feng T, Shi X and Dai J*. Matrix metalloproteinase 3 promotes cellular anti-Dengue virus response via interaction with transcription factor NFκB in cell nucleus, PLoS One, 2013 in press. (Corresponding author).


Team Members

Tingting Feng, Ph.D.,

Lecturer

Dr. Feng received her Ph.D. degree in Hydrobiology from Northwest Agriculture & Forest University in 2012. In 2012, she became a staff member of Institutes of Biology and Medical Sciences. Her research interests revolve around the infection and pathogenesis mechanisms of vector-borne pathogens, as well as prevention of tick-borne diseases. She has published 10 papers in referred journals in her field and presented at national academic meetings.

Selected publications

  1.      Feng,T., H. Zhang, H. Liu, Z. Zhou, D. Niu, L. Wong, H. Kucuktas, X. Liu, E. Peatman, and Z. Liu. 2011. Molecular characterization ande­xpression analysis of the channel catfish cathepsin D genes. Fish & shellfish immunology 31:164-169.

  2. Zuo, X., W. Pan, T. Feng, X. Shi, and J. Dai. 2014. Matrix Metalloproteinase 3 Promotes Cellular Anti-Dengue Virus Response via Interaction with Transcription Factor NFkappa B in Cell Nucleus. PloS one 9:e84748.

  3. Pan, W., X. Zuo, T. Feng, X. Shi, and J. Dai. 2012.Guanylate-binding protein 1 participates in cellular antiviral response to dengue virus. Virology journal 9:292.



WenPan, M.Sc,

Technician

Wen Pan achieved her Master degree in biochemistry and molecular biology from Xiamen University in 2011. She joined Dr. Jianfeng Dai's lab in the Institutes of Biology and Medical Sciences as a technician at the same year. Her research interests mainly focus on virus infection and immunity, and protein modification in immune modulation.


E-maildaijianfeng@suda.edu.cn

Office:Dushu Lake 703-B415

Office Tel:(86)512 658 82472