Laboratories

Principal Investigator

Wei Xu Ph.D.

Professor of IBMS


DrXu got her Ph.D. degree of Immunology from Fudan University in 2003 and post-doctoral experience in FRE2736-BioMerieux, France. Served as lecturer (2003), Assoc. Prof.（2006）in Fudan University. Her research focuses on anti-infection immunity and molecular designing of vaccines. She has more than 100 publications in Hepatology,Cir Res, J Immunol, J Virol, PLOS One, Vaccine et al and has 4 authorized patents and 8 waving patents. She gave oral presentation at 13th and 14th International Congress of Immunology at Brazil and Japan. She acts as co-author in 11 books of Immunology(2 in English). She is skilled in teaching which won her an Elaborate Course of Fudan University (Vaccines changes our world).


Research Interest

  1. Innate recognition of microbes and significance in pathogenesis of tuberculosis and viral myocarditis

  2. Regulation of host immunity by microflora

  3. Class switch mechanism of SIgA at mucosal site

  4. Molecular designing of novel TB vaccines

Selected publications:

  1. Cao Y, Xu W (co-corresponding author), Xiong S. Adoptive Transfer of Regulatory T Cells Protects against Coxsackievirus B3-Induced Cardiac Fibrosis. PLoS One. 2013 Sep 4;8(9):e74955.

  2. Ai W, Yue Y, Xiong S, Xu W. Enhanced protection against pulmonary mycobacterial challenge by chitosan-formulated polyepitope genevaccine was associated with elevated pulmonary SIgA and IFN-γ(+) T cell response. Microbiol Immunol. 2013 Mar; 57(3):224-35.

  3. Qian Q, Xiong S, Xu W. Manipulating intestinal immunity and microflora: an alternative solution to viral myocarditis? Future Microbiol. 2012; 7(10):1-10.

  4. Yue Y, Xu W (co-corresponding author), Xiong S. Modulation of Immunogenicity and Immunoprotection of Mucosal Vaccine Against Coxsackievirus B3 by Optimizing the Co-administration Mode of Lymphotactin Adjuvant. DNA Cell Biol. 2012 Apr;31(4):479-88.


Team members


LinWei Ph.D.,

Lecturer

Dr. Wei received his Ph.D. degree in microbiology at Nanjing Agricultural University in 2013. And he joined in Prof. Xu’s Lab of Institutes of Biology and Medical Sciences. His research interests focus on antimicrobial peptide and innate immunity, revolve around directional mining of natural antimicrobial agents based on biological survival strategy, and their functions and mechanisms against pathogens. He has more than 10 publications inpeer-reviewed journals such as FASEB J, J Med Chem, Biochimie.

Selected publications:

  1. Wei, L., J.Wu, H. Liu, H. L. Yang, M. Q. Rong, D. S. Li, P. H. Zhang, J. Y. Han, and R.Lai. 2013. A mycobacteriophage-derived trehalose-6,6 '-dimycolate-bindingpeptide containing both antimycobacterial and anti-inflammatory abilities.Faseb J 27:3067-3077.

  2. Wei, L., J.J. Yang, X. Q. He, G. X. Mo, J. Hong, X. W. Yan, D. H. Lin, and R. Lai. 2013.Structure and Function of a Potent Lipopolysaccharide-Binding Antimicrobial andAnti-inflammatory Peptide. J Med Chem 56:3546-3556.

  3. Yan, H. L.,Y. Y. Liu, J. Tang, G. X. Mo, Y. Z. Song, X. W. Yan, L. Wei, and R. Lai. 2013. A Novel Antimicrobial Peptide from Skin Secretions of the Tree Frog Thelodermakwangsiensis. Zool Sci 30:704-709.

  4. Yan, H. L.,L. Wei(co-first author), X. Q. He, H. Liu, S. L. Yang, R. Lai,and D. Q. Rao. 2012. A novel myotropic peptide from the skin secretions of thetree frog, Polypedates pingbianensis. Biochimie 94:1718-1723.

  5. Wei, L., L. Dong, T. Y. Zhao, D. W. You, R. Liu, H. Hu, H. L. Yang, and R. Lai. 2011. Analgesic and anti-inflammatory effects of the amphibian neurotoxin,anntoxin. Biochimie 93:995-1000.


Min Li Ph.D.,

Lecturer

Dr. Li received her M.D. degree in immunology from Zhejiang University in 2013. In 2013, she became a staff member of Institutes of Biology and Medical Sciences. Her research interests the role of zinc finger proteins in the development, differentiation and activation of immune cells. She has published several papers in referred journals in her field. 

Selected publications:

  1. Zhang, W., X. Wang, X. Xia, X. Liu, S. Suo, J. Guo, M. Li, W. Cao, Z. Cai, Z. Hui, M. Subramaniam, T. C. Spelsberg, J.Wang, and L. Wang. 2013. Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages. European journal of immunology 43:258-269.

  2. Li, M., W. Cao, H. Liu, W. Zhang, X. Liu, Z. Cai, J. Guo, X. Wang, Z. Hui, H. Zhang, J. Wang, and L. Wang. 2012. MCPIP1 down-regulates IL-2 e­xpression through an ARE-independent pathway. PloSone 7:e49841.

  3. Cai, Z., W. Zhang, M. Li, Y. Yue, F. Yang, L. Yu, X. Cao, and J. Wang. 2010. TGF-beta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells. Cellular & molecular immunology 7:35-43.


Fei Xiong M.Sc.,

Technician

Fei Xiong got his Master degree in Basis of Integrative Medicine from Nanjing University of Chinese Medicine in 2011 and he joined Dr.Wei Xu’s lab in the Institutes of Biology and Medical Sciences as a technician at the same year. His research interests mainly focus on the anti-infection immunity.



E-mail：xuwei828@suda.edu.cn

Office：Dushu lake 703-B321

Office Tel：(86)512 658 82431