Professor Jörg Timm
Vice Dean for Research, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Prof. Timm studied at Medical school of Universities of Münster (1992-94)and Bonn (1994-99). Also, he was a research fellow at the Partners AIDS Research Center in Massachusetts General Hospital. In 2014, he became a Professor for Virology (W3) and a director of the Institute of Virology at Heinrich-Heine University in Düsseldorf. Since 2016, Jörg has been a Vice Dean for Research at Heinrich-Heine University. Now, his team is focusing on studying immune regulation during infections with HBV and HCV.
Selected publications:
1.Wolski, D, Foote PK, Chen D, Lewis-Ximenez L, Fauvelle C, Aneja J, Walker A, Tonnerre P, Torres-Cornejo A, Imam S, Waring MT, Tully C, Allen TM, Chung RT, Timm J, Haining WN, Kim AY, Baumert T, Lauer GM. 2017. Early transcriptional divergence marks virus-specific primary human CD8+ T cells in chronic versus acute infection. Immunity, in press.
2.Thöns C, Senff T, Hydes TJ, Manser AR, Heinemann FM, Heinold A, Heilmann M, Kim AY, Uhrberg M, Scherbaum N, Lauer GM, Khakoo SI, Timm J. HLA-Bw4 80(T) and multiple HLA- Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs. Journal of Hepatology 2017 Apr 12. pii: S0168-8278(17)30213-1.
3.Kefalakes H, Jochum C, Hilgard G, Kahraman A, Bohrer AM, El Hindy N, Heinemann FM, Verheyen J, Gerken G, Roggendorf M, Timm J. 2015. Decades after recovery from hepatitis B and HBsAg clearance the CD8+ T cell response against HBV core is nearly undetectable. Journal of Hepatology 63:13-19.
4.Kefalakes H, Budeus B, Walker A, Jochum C, Hilgard G, Heinold A, Heinemann FM, Gerken G, Hoffmann D, Timm J. 2015. Adaptation of the hepatitis B virus core protein to CD8(+) T-cell selection pressure. Hepatology 62:47-56.
5.Thoens C, Berger C, Trippler M, Siemann H, Lutterbeck M, Broering R, Schlaak J, Heinemann FM, Heinold A, Nattermann J, Scherbaum N, Alter G, Timm J. 2014. KIR2DL3(+)NKG2A(-) natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs. Journal of Hepatology 61:475-481.
6.Ziegler S, Ruhl M, Tenckhoff H, Wiese M, Heinemann FM, Horn PA, Spengler U, Neumann- Haefelin C, Nattermann J, Timm J. 2013. Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes. Journal of Hepatology 58:24-30.
7.Ruhl M, Knuschke T, Schewior K, Glavinic L, Neumann-Haefelin C, Chang DI, Klein M, Heinemann FM, Tenckhoff H, Wiese M, Horn PA, Viazov S, Spengler U, Roggendorf M, Scherbaum N, Nattermann J, Hoffmann D, Timm J. 2011. CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins. Gastroenterology 140:2064-2073.
8.Giugliano S, Oezkan F, Bedrejowski M, Kudla M, Reiser M, Viazov S, Scherbaum N, Roggendorf M, Timm J. 2009. Degree of cross-genotype reactivity of hepatitis C virus-specific CD8+ T cells directed against NS3. Hepatology 50:707-716.
9.Timm J, Li B, Daniels MG, Bhattacharya T, Reyor LL, Allgaier R, Kuntzen T, Fischer W, Nolan BE, Duncan J, Schulze zur Wiesch J, Kim AY, Frahm N, Brander C, Chung RT, Lauer GM, Korber BT, Allen TM. 2007. Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution. Hepatology 46:339-349.
10.Timm J, Lauer GM, Kavanagh DG, Sheridan I, Kim AY, Lucas M, Pillay T, Ouchi K, Reyor LL, Schulze zur Wiesch J, Gandhi RT, Chung RT, Bhardwaj N, Klenerman P, Walker BD, Allen TM. 2004. CD8 epitope escape and reversion in acute HCV infection. The Journal of Experimental Medicine 200:1593-1604.