Professor Verena Keitel
W2 Professor for Hepatobiliary Transport physiology at Heinrich-Heine University Düsseldorf.
Professor Verena Keitel studied medical sciences at Ruprecht-Karls-University Heidelberg, the Imperial College in London/GB, at Duke University in Durham/USA and at National Hospital for Neurology and Neurosurgery in London/GB. Since 2011, she has become a Project Leader of dozens of research programs and has published more than sixty papers on top journals including Cancer Cell, Hepatology, GUT etc. Professor Verena Keitel is now the director of Hepatobiliary Transport physiology at Heinrich-Heine University in Düsseldorf. Now, her team is focusing on studying the roles of TGR5 in liver diseases.
Selected publications:
1．Patel KR, Harpavat S, Finegold M, Eldin K, Hicks J, Firan M, Keitel V, Kubitz R, Wu H. Post-transplant Recurrent Bile Salt Export Pump Disease: A Form of Antibody-mediated Graft Dysfunction and Utilization of C4d. J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):364-369.
2．Deutschmann K, Reich M, Klindt C, Dröge C, Spomer L, Häussinger D, Keitel V. Bile acid receptors in the biliary tree: TGR5 in physiology and disease. Biochim Biophys Acta. 2017 Aug 25. pii: S0925-4439(17)30303-4.
3．Dröge C, Bonus M, Baumann U, Klindt C, Lainka E, Kathemann S, Brinkert F, Grabhorn E, Pfister ED, Wenning D, Fichtner A, Gotthardt DN, Weiss KH, McKiernan P, Puri RD, Verma IC, Kluge S, Gohlke H, Schmitt L, Kubitz R, Häussinger D, Keitel V. Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants. J Hepatol. 2017 Dec;67(6):1253-1264.
4．Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor
TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 2017 Jun12;31(6):771-789.e6.
5．Gowert NS, Klier M, Reich M, Reusswig F, Donner L, Keitel V, Häussinger D, Elvers M. Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice. Cell Physiol Biochem. 2017;41(6):2133-2149.
6．Reich M, Klindt C, Deutschmann K, Spomer L, Häussinger D, Keitel V. Role ofthe G Protein-Coupled Bile Acid Receptor TGR5 in Liver Damage. Dig Dis. 2017;35(3):235-240.
7．Honke N, Shaabani N, Hardt C, Krings C, Häussinger D, Lang PA, Lang KS, Keitel V. Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection. Cell Physiol Biochem. 2017;41(1):323-338.
8．Häussinger D, Keitel V. Dual role of the bile acid receptor Takeda G-protein-coupled receptor 5 for hepatic lipid metabolism in feast and famine. Hepatology. 2017 Mar;65(3):767-770.
9．Greife A, Felekyan S, Ma Q, Gertzen CG, Spomer L, Dimura M, Peulen TO, Wöhler C, Häussinger D, Gohlke H, Keitel V, Seidel CA. Structural assemblies of the di- and oligomeric G-protein coupled receptor TGR5 in live cells: an MFIS-FRET and integrative modelling study. Sci Rep. 2016 Nov 11;6:36792.
10．Karababa A, Groos-Sahr K, Albrecht U, Keitel V, Shafigullina A, Görg B, Häussinger D. Ammonia Attenuates LPS-Induced Upregulation of Pro-Inflammatory Cytokine mRNA in Co-Cultured Astrocytes and Microglia. Neurochem Res. 2017 Mar;42(3):737-749.