Professor Julia Hauer
Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University, Düsseldorf, Germany.
Prof. Hauer got his MD at the Ludwig-Maximilian University, Munich, Germany in 2004. Since 2009, Prof. Hauer has become a Physician-Scientist of Clinic for Pediatric Oncology, Hematology and Clinical Immunology at Heinrich-Heine University in Düsseldorf. Prof. Hauer won several esteem international awards and prizes like Reinhard and Emmi Heynen Prize for outstanding scientific work and Award from the “Freunde und Förderer der Heinrich Heine Universität” for the best research project. Now, her team focuses on studyingacute lymphoblastic leukemia and other immune diseases.
Selected publications:
1.Activation-induced cytidine deaminase prevents pro-B cell acute lymphoblastic leukemia by functioning as a negative regulator in Rag1 deficient pro-B cells.Deborah Ingenhag, Stefan Pinkert, Sven Kracker, Salima Hacein-Bey-Abina, Marina Cavazzana, Michael Gombert, Alberto Martin-Lorenzo, Min-hui Lin, Carolina Vicente- Dueñas, Isidro Sánchez-García, Arndt Borkhardt, Julia Hauer. Oncotarget 2017 in press
2.Infection exposure promotes ETV6-RUNX1 precursor B cell leukemia via impaired H3K4 demethylases. Rodríguez-Hernández G, Hauer J, Martín-Lorenzo A, Schäfer D, Bartenhagen C, García- Ramírez I, Auer F, González-Herrero I, Ruiz-Roca L, Gombert M, Okpanyi V, Fischer U, Chen C, Dugas M, Bhatia S, Linka RM, Garcia-Suquia M, Rascón-Trincado MV, Garcia- Sanchez A, Blanco O, García-Cenador MB, García-Criado FJ, Cobaleda C, Alonso-López D, De Las Rivas J, Müschen M, Vicente-Dueñas C, Sánchez-García I, Borkhardt A. Cancer Res. 2017 Aug 15;77(16):4365-4377.* contributed equally
3.Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing.Bartenhagen C, Fischer U, Korn K, Pfister SM, Gombert M, Chen C, Okpanyi V, Hauer J, Rinaldi A, Bourquin JP, Eckert C, Hu J, Ensser A, Dugas M, Borkhardt A Haematologica. 2017 May;102(5):e179-e183.
4.Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.Ripperger T, Bielack SS, Borkhardt A, Brecht IB, Burkhardt B, Calaminus G, Debatin KM, Deubzer H, Dirksen U, Eckert C, Eggert A, Erlacher M, Fleischhack G, Frühwald MC, Gnekow A, Goehring G, Graf N, Hanenberg H, Hauer J, Hero B, Hettmer S, von Hoff K, Horstmann M, Hoyer J, Illig T, Kaatsch P, Kappler R, Kerl K, Klingebiel T, Kontny U, Kordes U, Körholz D, Koscielniak E, Kramm CM, Kuhlen M, Kulozik AE, Lamottke B, Leuschner I, Lohmann DR, Meinhardt A, Metzler M, Meyer LH, Moser O, Nathrath M, Niemeyer CM, Nustede R, Pajtler KW, Paret C, Rasche M, Reinhardt D, Rieß O, Russo A, Rutkowski S, Schlegelberger B, Schneider D, Schneppenheim R, Schrappe M, Schroeder C, von Schweinitz D, Simon T, Sparber-Sauer M, Spix C, Stanulla M, Steinemann D, Strahm B, Temming P, Thomay K, von Bueren AO, Vorwerk P, Witt O, Wlodarski M, Wössmann W, Zenker M, Zimmermann S, Pfister SM, Kratz CP. Am J Med Genet A. 2017 Apr;173(4):1017-1037
5.Mouse models for pre-clinical drug testing in leukemia. Bhatia S, Daschkey S, Lang F, Borkhardt A, Hauer J. Expert Opin Drug Discov. 2016 Nov;11(11):1081-1091
6.Infection exposure is a causal factor in B-precursor acute lymphoblastic leukemia as a result of Pax5 inherited susceptibility.Martin-Lorenzo A*, Hauer J*, Vicente-Duenas C*, Auer F, Gonzalez-Herrero I, Garcia- Ramirez I, Ginzel S, Thiele R, Constantinescu SN Prof, Bartenhagen C, Dugas M, Gombert M, Schafer D, Blanco O, Mayado A, Orfao A, Alonso-Lopez D, De Las Rivas J, Cobaleda C, Garcia-Cenador MB, Garcia-Criado FJ, Sanchez-Garcia I, Borkhardt A. Cancer Discov. 2015 Dec;5(12):1328-43. Highlighted in Nature and Nature Review Cancer
7.Genetically engineered mouse models of human B-cell precursor leukemias. Hauer J, Borkhardt A, Sánchez-García I, Cobaleda C.Cell Cycle. 2014;13(18):2836-46.
8.Recombination-activating gene 1 (Rag1)-deficient mice with severe combined immunodeficiency treated with lentiviral gene therapy demonstrate autoimmune Omenn-like syndrome.van Til NP, Sarwari R, Visser TP, Hauer J, Lagresle-Peyrou C, van der Velden G, Malshetty V, Cortes P, Jollet A, Danos O, Cassani B, Zhang F, Thrasher AJ, Fontana E, Poliani PL, Cavazzana M, Verstegen MM, Villa A, Wagemaker G. J Allergy Clin Immunol. 2013 Dec 8. pii: S0091-6749(13)01560-1.
9.Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A. Auer F, Rüschendorf F, Gombert M, Husemann P, Ginzel S, Izraeli S, Harit M, Weintraub M, Weinstein OY, Lerer I, Stepensky P, Borkhardt A, Hauer J.Leukemia. 2013 Nov 29. doi: 10.1038/leu.2013.363.