Professor Jürgen Scheller
Professor for Biochemistry and Molecular Biology (W3), Director of the Institute of Biochemistry and Molecular Biologie II, Medical Faculty, Heinrich-Heine University of Düsseldorf, Germany.
Jürgen Scheller did his research at University of Göttingen and Christian-Albrecht-University of Kiel in 2007. In 2008, he became a Professor for Biochemistry (W2) at Christian-Albrechts-University of Kiel. Since 2010, Prof. Scheller has been a director of the Institute of Biochemistry and Molecular Biologie II Heinrich-Heine University of Düsseldorf. Now, his team focuses on studying the effect of gp130 on IL-6.
Selected publications:
1. Hummel, T.M., Ackfeld, T., Schönberg, M., Ciupka, G., Schulz, F., Oberdoerster, A., Scheller, J. and Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation. Mol Cell Biol 37 doi: 10.1128/MCB.00014-17
2. Monhasery, N., Moll, J., Cuman, C., Franke, M., Lamertz, L., Nitz, R., Görg, B., Häussinger, D., Lokau, J., Floss, D.M., Piekorz, R., Dimitriadis, E., Garbers, C. and Scheller, J（2016）Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor. Cell Rep. 2016 Jul 26;16(4):1067-81.
3. Lokau, J., Nitz, R., Agthe, M., Monhasery, N., Aparicio-Siegmund, S., Schumacher, N., Wolf, J., Möller-Hackbarth, K., Waetzig, G.H., Grötzinger, J., Müller-Newen, G., Rose-Jhon, S., Scheller, J. Proteolytic Cleavage Governs Interleukin-11 Trans-signaling. Cell Rep 14, 1761-1773.
4. Geissler, R., Simkin, A., Floss, D., Patel, R., Fogarty, E.A., Scheller, J. and Grimson, A. (2016) A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1. Genes Dev 30, 1070-85.
5.Floss, D. M., Mrotzek, S., Klöcker, T., Schröder, J., Grözinger, J., Rose-John, S., and Scheller, J. (2013) Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor. J Biol Chem 288, 19386-19400
6.Chalaris, A., Adam, N., Sina, C., Rosenstiel, P., Paliga, K., Lehmann, J., Schirmacher, P., Hartmann,D., Cichy, J., Gavrilowa, O., Schreiber, S., Jostock, T., Matthews, V., Häsler, R., Becker, C., Neurath, M. F., Reiß, K., Scheller, J.*, and Rose-John, S.* (2010) Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med 207, 1617-1624 *corresponding author
7.Rabe, B., Chalaris, A., May, U., Waetzig, G. H., Seegert, D., Williams, A. S., Jones, S. A., Rose-John, S., and Scheller, J. (2008) Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 111, 1021-1028
8.Chalaris, A., Rabe, B., Paliga, K., Lange, H., Laskay, T., Fielding, C. A., Jones, S. A., Rose-John, S., and Scheller, J. (2007) Apoptosis is a natural stimulus of IL6R shedding and contributes to the pro-inflammatory trans-signaling function of neutrophils. Blood 110, 1748-1755
9.Scheller, J., Guhrs, K. H., Grosse, F., and Conrad, U. (2001) Production of spider silk proteins in tobacco and potato. Nat Biotechnol 19, 573-577