报告题目：The roles of mir-125b inimmunity and leukemic development
报告人：Alex Steven (Yick-Lun) So
报告时间：15:00-16:00,2014年4月14日（周一）
报告地点：IBMS学术报告厅（独墅湖校区703栋4楼3401室）
Alex Steven (Yick-Lun) So,Ph.D.
PROFILE
Immunologist and molecularbiologist specializing in microRNA-mediated leukemic development using mouse models. Experienced in mentoring, grant writing, and scientific presentation.
EDUCATION
California Institute of Technology, Pasadena, CA 2008 – present Post-Doctoral Fellow (Biology)
University of California San Francisco, San Francisco, CA 2002 – 2007 Ph.D., Chemistry and Chemical Biology
University of Westminster,London, England 2001 Study Abroad Program
Skidmore College, Saratoga Springs, NY 1995 - 1998 B.A.,Chemistry Major with Biochemistry Concentration
RESEARCH EXPERIENCE
California Institute ofTechnology, Pasadena, CA 2008 - Present Post-Doctoral Fellow
1）Investigatingthe cellular and molecular mechanism by which microRNA-125b regulates bothhematopoiesis as well as leukemia in mice
2）Determiningthe role of the Bach1 protein in autoimmunity, T cell immunity, and developmentof antigen presenting cells in mice.
University of California SanFrancisco, San Francisco, CA2007 –2008 Staff Research Associate
1）Studiedthe mechanism by which the glucocorticoid receptor initiates and maintain scircadian rhythm in stem cells
2）Examinedthe functional role of circadian rhythm genes in adipocyte cell fate
University of California San Francisco, San Francisco,CA2002 – 2007Ph.D. Student
1）Examinedthe determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor
2）Applied computational and conservation analyses to predict global occupancy of glucocorticoid receptor binding in mammalian genomes.
PUBLICATIONS
1) So AY* & Zhao JL*, Baltimore D, “The Yin and Yang of microRNAs:leukemia and immunity” Immun. Rev, 2012.*Co-first authors
2) So AY, Garcia-Flores Y, Minisandram A, Martin A, Taganov K, BoldinM, Baltimore D, “Regulation Of APC Development,Immune Response, and Autoimmunity by Bach1/HO-1 Pathway in Mice” Blood,2012.
3) Chaudhuri AA* & SoAY*, Mehta A, Minisandram A, Sinha N, Jonsson VD, Rao DS, O’Connell RM,Baltimore D, “Oncomir MiR-125b RegulatesHematopoiesis by Targeting the Gene Lin28A” PNAS, 2012. *Co-first authors
4) Chaudhuri AA* & So AY*, Sinha N, Gibson WS, O’ConnellRM, Baltimore D, “MicroRNA-125b Potentiates Macrophage Activation” Journal ofImmunology, 2011.*Co-first authors
5) Maria Jose Costa* & So AY*, Kaasik K, Pillsbury ML, Fu YH,Ptacek LJ, Yamamoto KR, Feldman BJ, “Circadian Clock Gene Period3 is anInhibitor of the Adipocyte Cell Fate” JBC, 2011.*Co-first authors
6) So AY, de la Fuente E, Walter P, Shuman M, Bernales S, “Theunfolded protein response during prostate cancer development” Cancer MetastasisRev, 2009.
7) So AY, Bernal TU, Pillsbury M, Yamamoto, KR, Feldman BJ,“Glucocorticoid regulation of the circadian clock modulates glucosehomeostasis” PNAS, 2009.
8) So AY, Cooper S., Feldman BJ, Manuchehri M, Yamamoto KR,“Conservation Analysis Predicts In Vivo Occupancy of Glucocorticoid ReceptorBinding Sequences at Glucocorticoid-Induced Genes” PNAS, 2008.
9) So AY, Chivorapol C, Bolton EC, Li H, Yamamoto KR, “Determinants OfCell- and Gene-Specific TranscriptionalRegulation by the Glucocorticoid Receptor” PLoS Genetics, 2007.