课题组负责人
戴建锋 博士,苏州大学教授,博士生导师
戴建锋教授,2001年获得复旦大学生物学学士学位。2006年在复旦大学遗传学研究所,遗传工程国家重点实验室获得博士学位。2006年至2011年,留学美国耶鲁大学医学院,在著名虫媒传染病专家Erol Fikrig教授实验室从事博士后研究。2011年6月入职苏州大学生物医学研究院,任教授,博导。主要研究方向为抗感染免疫和虫媒传染病。实验室累计主持国家自然科学基金10余项,省部级基金5项。参与教育部创新团队、教育部重点实验室,江苏省创新团队、江苏省重点实验室、江苏省优势学科等项目多项。在Cell Host Microbe,Nature Communications,Hepatology,Advanced Science,EMBO Reports,Science Bulletins等学术期刊发表论文100余篇,获得国家发明专利授权7项。担任中国病理生理学会系统生物医学专委会委员,中国昆虫学会媒介昆虫与病原互作专委会委员,江苏省免疫学会理事等学术职务。
主要研究方向
1、虫媒传染病和医学媒介生物
2、病毒感染和宿主抗病毒免疫
3、传染病疫苗和小分子药物
课题组成员
王俊 博士,副教授,硕士生导师
王俊,2001/2004年获得南京大学生物学学士/硕士学位,2011年获荷兰莱顿大学医学中心免疫学博士学位,2012年加入苏州大学生物医学研究院任副教授。王俊博士目前的研究方向主要为炎症、肿瘤和感染性疾病中T、B细胞发育和功能的调控及分子机制。主持教育部留学回国人员科研启动基金和4项国家自然科学基金,参与国家重点研发计划等项目。累计发表40余篇SCI论文,入选苏州市高等院校、科研院所紧缺高层次人才和江苏省“博士集聚计划”。
潘文硕士,高级实验师
潘文于2011年获得厦门大学生化与分子生物学硕士学位,同年加入苏州大学生物医学研究院戴建锋教授课题组担任技术员职位,现任实验室高级实验师。
代表性论文
1.Lei Z, Gu Y, Liu Y, Liu H, Lu X, Chen W, Zhou L, Pan P, Chen Z, Yue Z, Ruan J, Zhu L, Li G, Xia X, Yu Y*, Dai J*, Chen X*. Identification of antiviral RNAi regulators ILF3/DHX9 recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly. Nature Communications, 2025, 16:1991
2.Zhu J, Wu R, Yang T, Yuan Y, Liu G, Chen S, Chen Z, Liu S, Wang S, Li D, Yao H, He Y, He S, Qin CF*, Dai J*, Ma F*. Harnessing ZIKV NS2A RNA for alleviating acute hepatitis and cytokine release storm by targeting translation machinery. Hepatology. 2025 Jul 1;82(1):110-126.
3.Huang C, Jiang T, Pan W, Feng T, Zhou X, Wu Q,Ma F*, Dai J*, Ubiquitination of NS1 Confers Differential Adaptation of Zika Virus in Mammalian Hosts and Mosquito Vectors, Advanced Science,2024 19:e2408024.
4.Chen Z, Zhang J, Wang J, Tong H, Pan W, Ma F*, Wu Q*, Dai J*. N6-methyladenosine RNA modification promotes Severe Fever with Thrombocytopenia Syndrome Virus infection. PLoS Pathog. 2024 Nov 25;20(11):e1012725.
5.Zhao Y*, Man R, Zheng JB, Zhang L, Liu LM, Zhou X, Zhao LM*, van Eck M, Wang J*. Enhanced B-1 self-renewal and attenuated atherosclerosis lesion development in Cd19cre/+Ldlr-/- mice on Western-type diet. Atherosclerosis. 2025 Aug; 407:120406.
6.Hu MM, Zhao Y, Zhang N, Gong FY, Zhang W, Dong CS, Dai JF*, Wang J*. Tumor microenvironment: obstacles and opportunities for T-cell based tumor immunotherapies, Mol Cancer Res. 2025 Apr 1;23(4):277-287.
7.Gao H, Zhao Y, Zhao S, Dai XQ, Qin XY, Zheng WL, He TT, Zhang N, Zhu C, Wang HM, Pan W, Zhu XM, Gao XM, Dai JF*, Gong FY*, Wang J*. The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis. Cell Mol Biol Lett. 2024 Sep 14; 29(1):123.
8.Jiang T, Huang C, Ruan Q, Huang X, Liang C, Chen Z, Yu X, Peng Y, Liu Z, Cheng G, Dai J*, Sun J*. Envelope domain III E324, E351, and E380 mutations lever adaptive evolution of DENV-1 genotype I. J Virol. 2024 Sep 4:e0118324.
9.Zhao Y*, Zhang L, Liu L, Zhou X, Ding F, Yang Y, Du S, Wang H, Van Eck M, Wang J*. Specific loss of ABCA1 (ATP-binding cassette transporter A1) suppresses TCR (T-cell receptor) signaling and provides protection against atherosclerosis. Arterioscler Thromb Vasc Biol. 2022 Dec; 42(12):e311-e326.
10.Wang K, Huang C, Jiang T, Chen Z, Xue M, Zhang Q, Zhang J, Dai J*, RNA-binding protein RBM47 stabilizes IFNAR1 mRNA to potentiate host antiviral activity, EMBO Rep, 2021: e52205.
11.Wang K, Zhang J, Ge Y, Dong C, Dai J*. Cyclovirobuxine D inhibits Dengue virus replication by impeding the complete autophagy via a cholesterol-dependent manner, Science Bulletin, 2021 Feb, 66(3):284-296
12.Wang K, Zou C, Wang X, Huang C, Feng T, Pan W, Wu Q, Wang P, Dai J*. Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3. PLoS Pathog. 2018 Aug 24;14(8):e1007287.
13.Liu L#, Dai J#*, Zhao YO, Narasimhan S, Yang Y, Zhang L, and Fikrig E. The Ixodesscapularis JAK-STAT pathway regulatestick antimicrobial peptides, thereby controlling the agent of human granulocyticanaplasmosis,J Infect Dis, 2012 Oct;206(8):1233-41.
14.Dai J, Narasimhan S, Zhang L, Liu L, Wang P and Fikrig E. Tick histamine release factor is critical for Ixodesscapularis engorgement and transmission of Lyme disease agent. PLoS Pathog. 2010;6(11):e1001205.
15.Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, and Fikrig E. Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent. Cell Host & Microbe. 2009;6(5):482-92.
16.Dai J, Wang PH, Bai FW, et al. ICAM-1 participates in the entry of West Nile virus into the central nervous system. J Virol. 2008;82(8):4164-4168.
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